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Regulator of G-protein signaling, RGS superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Regulator of G-protein signaling, RGS [ 48096]
Superfamily:   Regulator of G-protein signaling, RGS [ 48097]
Families:   Regulator of G-protein signaling, RGS [ 48098] (9)


Superfamily statistics
Genomes (437) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,983 16,868 11
Proteins 6,393 15,654 11


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.0000000042790Least InformativeDirect
Biological Process (BP)response to stimulus0.00017070.000003476Least InformativeDirect
Biological Process (BP)cell communication0.00000013360Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.0000010150.000001324Moderately InformativeDirect
Biological Process (BP)single organism signaling0.0000027730Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.00027450Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.00084420Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus0.0094711Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.00090840.2103Moderately InformativeInherited
Biological Process (BP)response to organic substance0.016810.7878Moderately InformativeInherited
Biological Process (BP)regulation of response to stimulus0.0029990Moderately InformativeInherited
Biological Process (BP)response to nitrogen compound0.0000018350.016InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0041110.0003701InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.0071250.00023InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.00000000006740.002144InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway00Highly InformativeDirect
Biological Process (BP)regulation of GTPase activity00.00000000000005545Highly InformativeDirect
Biological Process (BP)positive regulation of hydrolase activity00.00000009482Highly InformativeDirect
Biological Process (BP)regulation of G-protein coupled receptor protein signaling pathway0.00000000023390Highly InformativeDirect
Molecular Function (MF)binding0.023030.5187Least InformativeInherited
Molecular Function (MF)molecular function regulator00Moderately InformativeDirect
Molecular Function (MF)enzyme activator activity00InformativeDirect
Molecular Function (MF)GTPase regulator activity00Highly InformativeDirect
Cellular Component (CC)membrane0.0061690.00000000009053Least InformativeInherited
Cellular Component (CC)cell projection0.00080510.00000000001153Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.034210.00000000000005256Moderately InformativeInherited
Cellular Component (CC)extrinsic component of membrane0.000000014030.000000009718InformativeDirect
Cellular Component (CC)neuron projection0.0000016310.000007786InformativeDirect
Cellular Component (CC)side of membrane0.000099170.000006153InformativeDirect
Cellular Component (CC)extrinsic component of cytoplasmic side of plasma membrane0.00000079140.00000000000005523Highly InformativeDirect
Cellular Component (CC)neuronal cell body0.000000080761Highly InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.000003476 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.000009632 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.1089 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.8971 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.000001324 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0001062 Moderately Informative Direct
Biological Process (BP) reproduction 0.0004228 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2103 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.7878 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.6518 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.07047 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.9026 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9745 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.2642 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6873 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.7856 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.6318 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.001857 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.2892 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.01397 Moderately Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.0003701 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000002399 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00023 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00002781 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0001159 Informative Direct
Biological Process (BP) supramolecular fiber organization 0.000005089 Informative Direct
Biological Process (BP) phosphorylation 0.000006139 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000006228 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00001879 Informative Direct
Biological Process (BP) multi-organism reproductive process 0.0000837 Informative Direct
Biological Process (BP) actin cytoskeleton organization 0.000211 Informative Direct
Biological Process (BP) regulation of organelle organization 0.0006939 Informative Direct
Biological Process (BP) generation of neurons 0.0007221 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0009014 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 0.009953 Informative Inherited
Biological Process (BP) regulation of system process 0.008709 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.016 Informative Inherited
Biological Process (BP) growth 0.1796 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.5854 Informative Inherited
Biological Process (BP) regulation of transferase activity 1 Informative Inherited
Biological Process (BP) negative regulation of molecular function 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.004517 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.9814 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.04232 Informative Inherited
Biological Process (BP) post-embryonic development 0.01354 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.9412 Informative Inherited
Biological Process (BP) negative regulation of cellular protein metabolic process 0.1304 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.1036 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.3862 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.003739 Informative Inherited
Biological Process (BP) locomotion 0.272 Informative Inherited
Biological Process (BP) localization of cell 0.4592 Informative Inherited
Biological Process (BP) epithelium development 0.001872 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.1792 Informative Inherited
Biological Process (BP) embryo development 0.1945 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.07333 Informative Inherited
Biological Process (BP) single organism reproductive process 0.1922 Informative Inherited
Biological Process (BP) cell development 0.131 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.5975 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.002144 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.001443 Informative Inherited
Biological Process (BP) microtubule-based process 0.01452 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of GTPase activity 0.00000000000005545 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00000009482 Highly Informative Direct
Biological Process (BP) regulation of G-protein coupled receptor protein signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.00000004462 Highly Informative Direct
Biological Process (BP) post-embryonic animal morphogenesis 0.000004909 Highly Informative Direct
Biological Process (BP) positive regulation of proteolysis 0.00000993 Highly Informative Direct
Biological Process (BP) phagocytosis 0.00001162 Highly Informative Direct
Biological Process (BP) regulation of protein processing 0.000119 Highly Informative Direct
Biological Process (BP) appendage development 0.0005716 Highly Informative Direct
Biological Process (BP) cell growth 0.001084 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.003236 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.01498 Highly Informative Inherited
Biological Process (BP) negative regulation of transferase activity 0.002417 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.05857 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.1205 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.1615 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.5444 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.01738 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.101 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.9465 Highly Informative Inherited
Biological Process (BP) regulation of MAP kinase activity 0.01688 Highly Informative Inherited
Biological Process (BP) cellular component disassembly 0.003847 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.5201 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.002008 Highly Informative Inherited
Biological Process (BP) cell-cell signaling 0.3864 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.04257 Highly Informative Inherited
Biological Process (BP) gastrulation 0.003877 Highly Informative Inherited
Biological Process (BP) microtubule-based movement 0.1444 Highly Informative Inherited
Molecular Function (MF) transferase activity 0.0008306 Least Informative Direct
Molecular Function (MF) binding 0.5187 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.00000000001721 Moderately Informative Direct
Molecular Function (MF) structural molecule activity 0.1686 Moderately Informative Inherited
Molecular Function (MF) anion binding 0.4379 Moderately Informative Inherited
Molecular Function (MF) enzyme activator activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000000000000001615 Informative Direct
Molecular Function (MF) kinase activity 0.00000000000005021 Informative Direct
Molecular Function (MF) phospholipid binding 0.000641 Informative Direct
Molecular Function (MF) enzyme binding 0.1862 Informative Inherited
Molecular Function (MF) receptor binding 0.1807 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.00001484 Highly Informative Direct
Molecular Function (MF) kinase binding 0.0003863 Highly Informative Direct
Molecular Function (MF) guanyl-nucleotide exchange factor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.00000000009053 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.05431 Least Informative Inherited
Cellular Component (CC) protein complex 0.5992 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8031 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.00000000001153 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00000000000005256 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.1522 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.004117 Moderately Informative Inherited
Cellular Component (CC) extrinsic component of membrane 0.000000009718 Informative Direct
Cellular Component (CC) neuron projection 0.000007786 Informative Direct
Cellular Component (CC) side of membrane 0.000006153 Informative Direct
Cellular Component (CC) cytoplasmic region 0.00000000417 Informative Direct
Cellular Component (CC) cilium 0.00001485 Informative Direct
Cellular Component (CC) apical part of cell 0.000143 Informative Direct
Cellular Component (CC) plasma membrane region 0.01329 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 0.901 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.03249 Informative Inherited
Cellular Component (CC) extrinsic component of cytoplasmic side of plasma membrane 0.00000000000005523 Highly Informative Direct
Cellular Component (CC) contractile ring 0.0000000000008818 Highly Informative Direct
Cellular Component (CC) cell division site part 0.000000002899 Highly Informative Direct
Cellular Component (CC) basal part of cell 0.000000008716 Highly Informative Direct
Cellular Component (CC) cortical cytoskeleton 0.00000858 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.00003422 Highly Informative Direct
Cellular Component (CC) neuronal cell body 1 Highly Informative Inherited
Cellular Component (CC) photoreceptor cell cilium 0.008018 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.000009129Moderately InformativeDirect
Biological processSensory transduction0InformativeDirect
Biological processWnt signaling pathway0InformativeDirect
Biological processTranslation regulation0.0004072InformativeDirect
Biological processVision0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentNucleus0.00000000007121Least InformativeDirect
Cellular componentCell projection0.000000000000793Moderately InformativeDirect
Cellular componentCell junction0.000004467Moderately InformativeDirect
Cellular componentEndosome0.000006087Moderately InformativeDirect
Cellular componentSynapse0.000000003731InformativeDirect
DomainCoiled coil0.0000008869Moderately InformativeDirect
Molecular functionLipid-binding0.00004209Moderately InformativeDirect
Post-translational modificationTransferase0.5916Least InformativeInherited
Post-translational modificationKinase2.221e-16Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000000000002195Moderately InformativeDirect
Post-translational modificationGTPase activation0InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationGuanine-nucleotide releasing factor0.0000000005134InformativeDirect
Post-translational modificationSignal transduction inhibitor0Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00000008915Moderately InformativeDirect
Post-translational modificationMethylation0.0009162Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000001553InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Regulator of G-protein signaling, RGS domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Regulator of G-protein signaling, RGS superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]