SUPERFAMILY 1.75 HMM library and genome assignments server

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Myeloperoxidase-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Heme-dependent peroxidases [ 48112]
Superfamily:   Heme-dependent peroxidases [ 48113] (3)
Family:   Myeloperoxidase-like [ 48132] (2)


Family statistics
Genomes (318) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,144 9,102 14
Proteins 2,037 8,666 14


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.00000000148Moderately InformativeDirect
Enzyme Commission (EC)Acting on single donors with incorporation of mole0.003667InformativeInherited
Enzyme Commission (EC)Peroxidases1InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)0Highly InformativeDirect
Enzyme Commission (EC)Peroxidase0.000000000004349Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0005749Moderately InformativeDirect
Disease Ontology (DO)benign neoplasm0.001141Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.02053Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.03534Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.2314Moderately InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.0006766InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.001625InformativeInherited
Disease Ontology (DO)peptic ulcer disease0.000005544Highly InformativeDirect
Disease Ontology (DO)cystic fibrosis0.0001178Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details) Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.6476Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.005562Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.01157Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating pituitary hormone level0.01415Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)body region morphology variant0.02522Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02522Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.02532Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.02542Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.02699Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.03968InformativeInherited
Worm Phenotype (WP)cuticle morphology variant0.000004276Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001964Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0002748Highly InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)endocrine system0.0008649Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0.4265Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.00000004938InformativeDirect
Enzyme Commission (EC)Intramolecular transferases0.01142InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.00000008715Highly InformativeDirect
Enzyme Commission (EC)Peroxidases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 41 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Heme-dependent peroxidases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]