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Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,314) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 58,076 218,529 76
Proteins 56,654 215,280 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.01395Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02752Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.0526InformativeInherited
Disease Ontology (DO)hypospadias0.0001294Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.000249Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.0009339Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06226Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6037Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.8703Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1547Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3478Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.8044Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.000526InformativeDirect
Phenotypic Abnormality (PA)Abnormal breast morphology0.04942InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1293InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.1355InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.3521InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000002241Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000002241Highly InformativeDirect
Phenotypic Abnormality (PA)Primary adrenal insufficiency0.0001627Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.004929Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.01318Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.03163Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.1207Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal enchondral ossification0.1436Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2302Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7949Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0008492Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2638Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00007049InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.05466InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.000007553Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0004304Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.2258Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.5681Moderately InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0002663InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.3855Least InformativeInherited
Fly Anatomy (FA)larva0.4518Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5743Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.5892Least InformativeInherited
Fly Anatomy (FA)nervous system0.6912Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03082Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.05831Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1378Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1822Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.5111Moderately InformativeInherited
Fly Anatomy (FA)head0.5479Moderately InformativeInherited
Fly Anatomy (FA)tract0.0001026InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0006724InformativeDirect
Fly Anatomy (FA)gut section0.002172InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01841InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.02197InformativeInherited
Fly Anatomy (FA)primordium0.03078InformativeInherited
Fly Anatomy (FA)hindgut0.000001118Highly InformativeDirect
Fly Anatomy (FA)commissure0.000005606Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.000009373Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004152Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001527Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.00088Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.3714Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6737Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage1Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.0003106Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01276InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.02743Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.6196InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen0.000000008587Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.00000004503Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.03157Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 117 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 117 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]