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Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,314) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 58,076 218,529 76
Proteins 56,654 215,280 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.01395Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02752Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.0526InformativeInherited
Disease Ontology (DO)hypospadias0.0001294Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.000249Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.0009339Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06419Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6134Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.8782Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1556Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3573Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.8165Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.0005805InformativeDirect
Phenotypic Abnormality (PA)Abnormal breast morphology0.0529InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1316InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.1391InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.3534InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.00000216Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.00000216Highly InformativeDirect
Phenotypic Abnormality (PA)Primary adrenal insufficiency0.0001557Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.004644Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.01487Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.03386Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.12Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal enchondral ossification0.1439Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2307Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7948Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0008463Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2635Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00007039InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.05456InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.000007539Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0004301Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.4007Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.6074Moderately InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.000158InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.05804InformativeInherited
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.0003685Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organism subdivision0.1168Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3516Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.5573Least InformativeInherited
Fly Anatomy (FA)nervous system0.6504Least InformativeInherited
Fly Anatomy (FA)cell0.6885Least InformativeInherited
Fly Anatomy (FA)larva0.7207Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02927Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.03344Moderately InformativeInherited
Fly Anatomy (FA)embryo0.09538Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1411Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1773Moderately InformativeInherited
Fly Anatomy (FA)head0.542Moderately InformativeInherited
Fly Anatomy (FA)tract0.00009369InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0002577InformativeDirect
Fly Anatomy (FA)gut section0.001926InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.004444InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01127InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01893InformativeInherited
Fly Anatomy (FA)primordium0.02836InformativeInherited
Fly Anatomy (FA)hindgut0.000001035Highly InformativeDirect
Fly Anatomy (FA)commissure0.000005822Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.00004072Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001323Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0004575Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0006315Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.2263Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.07731Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5139Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7491Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3979Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.115InformativeInherited
Zebrafish Anatomy (ZA)hypophysis0.0001338Highly InformativeDirect
Zebrafish Anatomy (ZA)male organism0.0008529Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6336Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage1Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.0001098Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01276InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases0.03005Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.6231InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen0.000000009636Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.00000004701Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.03234Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 117 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 117 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]