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Cytochrome P450 superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Families:   Cytochrome P450 [ 48265] (22)


Superfamily statistics
Genomes (1,314) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 58,076 218,529 76
Proteins 56,654 215,280 76


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7611Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)1InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.02235InformativeInherited
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)With a reduced iron-sulfur protein as one donor, a0.00000001495Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cardiovascular system disease0.00003287Least InformativeDirect
Disease Ontology (DO)connective tissue disease0.01389Moderately InformativeInherited
Disease Ontology (DO)endocrine system disease0.02749Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.05355InformativeInherited
Disease Ontology (DO)hypospadias0.0001291Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0002487Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.0009327Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.09141Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.5012Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.5883Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9483Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.2527Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.7051Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.02282InformativeInherited
Phenotypic Abnormality (PA)Abnormal breast morphology0.03216InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.1056InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.1229InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1399InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2867InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.3531InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cation homeostasis0.6079InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000001958Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000001958Highly InformativeDirect
Phenotypic Abnormality (PA)Primary adrenal insufficiency0.00006454Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0004705Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating cortisol level0.0007348Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.001134Highly InformativeInherited
Phenotypic Abnormality (PA)Polycystic ovaries0.004771Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.009543Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.1153Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal enchondral ossification0.1593Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2314Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7948Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0008475Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00007039InformativeDirect
Mammalian Phenotype (MP)abnormal circulating lipid level0.05451InformativeInherited
Mammalian Phenotype (MP)abnormal xenobiotic pharmacokinetics0.00000754Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0004307Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.2233Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0002341InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.3051Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.384Least InformativeInherited
Fly Anatomy (FA)larva0.4397Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5542Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.5835Least InformativeInherited
Fly Anatomy (FA)nervous system0.6745Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02865Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.03267Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.06394Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1312Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1719Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.495Moderately InformativeInherited
Fly Anatomy (FA)head0.5435Moderately InformativeInherited
Fly Anatomy (FA)tract0.0001083InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0006744InformativeDirect
Fly Anatomy (FA)midgut0.0007108InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.006758InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01898InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.02358InformativeInherited
Fly Anatomy (FA)primordium0.03266InformativeInherited
Fly Anatomy (FA)hindgut0.000001314Highly InformativeDirect
Fly Anatomy (FA)commissure0.000006009Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.000009846Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004424Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001672Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0009707Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval gut0.0366Highly InformativeInherited
Fly Anatomy (FA)embryonic epidermis0.3596Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.4202Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage1Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00002932Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.01276InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.8315InformativeInherited
Enzyme Commission (EC)Acting on single donors with incorporation of molecular oxygen (oxygenases). The oxygen incorporated1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With a heme protein as acceptor0.00000004154Highly InformativeDirect
Enzyme Commission (EC)With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen0.00000005177Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.03029Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited
Enzyme Commission (EC)With another compound as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR001128 SSF48264 Protein matches
Abstract

More information about these proteins can be found at Protein of the Month: Cytochrome P450.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 117 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 117 hidden Markov models representing the Cytochrome P450 superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]