SUPERFAMILY 1.75 HMM library and genome assignments server

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Cytochrome P450 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Family:   Cytochrome P450 [ 48265] (22)


Family statistics
Genomes (1,231) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,479 143,933 76
Proteins 35,014 142,677 76


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7873Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0003169InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0.7602Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.04084InformativeInherited
Disease Ontology (DO)hypospadias0.0001109Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07242Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6503Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9817Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1729Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1733Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.4346Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood ion concentration0.003376InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.05805InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.1166InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000001239Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000001239Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0008448Highly InformativeDirect
Phenotypic Abnormality (PA)Adrenal insufficiency0.001124Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.004463Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.008714Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2257Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7615Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.7743Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0004694Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1904Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2424Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.4024Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.0000553InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003852Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0003863InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.1098Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3234Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3915Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5705Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.6192Least InformativeInherited
Fly Anatomy (FA)larva0.6848Least InformativeInherited
Fly Anatomy (FA)nervous system0.709Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03032Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.05126Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1322Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1876Moderately InformativeInherited
Fly Anatomy (FA)tract0.0000984InformativeDirect
Fly Anatomy (FA)midgut0.0007554InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0007678InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.004135InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01167InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01838InformativeInherited
Fly Anatomy (FA)primordium0.02912InformativeInherited
Fly Anatomy (FA)hindgut0.0000007808Highly InformativeDirect
Fly Anatomy (FA)commissure0.000006606Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.000007048Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00003981Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001466Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0005638Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.309Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.08738Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3569Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6091Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3022Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.0259InformativeInherited
Zebrafish Anatomy (ZA)male organism0.0002839Highly InformativeDirect
Zebrafish Anatomy (ZA)female organism0.0006314Highly InformativeDirect
Zebrafish Anatomy (ZA)endocrine system0.004442Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.6149Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.0001605Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.02426InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0007873InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.6927InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.0313Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 117 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]