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Cytochrome P450 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Family:   Cytochrome P450 [ 48265] (22)


Family statistics
Genomes (1,231) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,479 143,933 76
Proteins 35,014 142,677 76


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7873Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0003169InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0.7602Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.04084InformativeInherited
Disease Ontology (DO)hypospadias0.0001109Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07738Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.661Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9836Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1734Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1741Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.4483Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal blood cation concentration0.0002864InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.05948InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.1199InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000001185Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000001185Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0008536Highly InformativeDirect
Phenotypic Abnormality (PA)Adrenal insufficiency0.001154Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.004227Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.009724Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2262Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7618Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.7741Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0004676Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1896Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2421Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.4023Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00005529InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003851Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.7225Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.2432Moderately InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0004389InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.04777InformativeInherited
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect
Worm Phenotype (WP)cadmium hypersensitive0.0002428Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.09687Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3531Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5379Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.588Least InformativeInherited
Fly Anatomy (FA)nervous system0.664Least InformativeInherited
Fly Anatomy (FA)larva0.7207Least InformativeInherited
Fly Anatomy (FA)digestive system0.004596Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.02864Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.02893Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.131Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1799Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.4998Moderately InformativeInherited
Fly Anatomy (FA)tract0.00009157InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0002566InformativeDirect
Fly Anatomy (FA)midgut0.0006981InformativeDirect
Fly Anatomy (FA)embryonic/larval digestive system0.003767InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01113InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.0186InformativeInherited
Fly Anatomy (FA)primordium0.02682InformativeInherited
Fly Anatomy (FA)hindgut0.0000007756Highly InformativeDirect
Fly Anatomy (FA)commissure0.000006335Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.00002839Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00003927Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval glial cell0.0001329Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001329Highly InformativeDirect
Fly Anatomy (FA)CNS glial cell0.0002248Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0005045Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.2095Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.06641Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3003Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7124Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3786Moderately InformativeInherited
Zebrafish Anatomy (ZA)endocrine system0.007027InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.03704InformativeInherited
Zebrafish Anatomy (ZA)hypophysis0.00009358Highly InformativeDirect
Zebrafish Anatomy (ZA)male organism0.0005153Highly InformativeDirect
Zebrafish Anatomy (ZA)female organism0.0009073Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.5739Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00005539Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.02426InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.000778InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.6855InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.03117Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 117 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]