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DNA repair protein MutS, domain III superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA repair protein MutS, domain III [ 48333]
Superfamily:   DNA repair protein MutS, domain III [ 48334]
Families:   DNA repair protein MutS, domain III [ 48335]


Superfamily statistics
Genomes (2,697) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,624 40,090 8
Proteins 6,592 39,990 8


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2487Least InformativeInherited
Disease Ontology (DO)urinary system cancer0.0008201InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.1671Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.207Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.2384Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.01347Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.04762Moderately InformativeInherited
Phenotypic Abnormality (PA)Gonadal neoplasm0.00001397InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the glial cells0.00002931InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the gastrointestinal tract0.0002435InformativeDirect
Phenotypic Abnormality (PA)Neoplasm by histology0.0004776InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the endocrine system0.000791InformativeDirect
Phenotypic Abnormality (PA)Abnormal intestine morphology0.005464InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.04923InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.128InformativeInherited
Phenotypic Abnormality (PA)Endometrial carcinoma0.00000003288Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.0000002807Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.0000004493Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.00000119Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the stomach0.000002744Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.000003587Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the rectum0.000008362Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the skin0.000091Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.002179Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.006444Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.009134Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.0408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal DNA repair0.00004565InformativeDirect
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0001809InformativeDirect
Mammalian Phenotype (MP)increased carcinoma incidence0.0002187InformativeDirect
Mammalian Phenotype (MP)abnormal mismatch repair0.0000000007307Highly InformativeDirect
Mammalian Phenotype (MP)increased skin tumor incidence0.000002983Highly InformativeDirect
Mammalian Phenotype (MP)increased alimentary system tumor incidence0.00001037Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.0000324Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)developmental timing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.005363Least InformativeInherited
Worm Phenotype (WP)sterile progeny0Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.0003621Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0004852Moderately InformativeDirect
Worm Phenotype (WP)cell division variant0.05571Moderately InformativeInherited
Worm Phenotype (WP)non apoptotic cell death variant0.0000007498InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect

Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR007696 SSF48334 Protein matches
Abstract

This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with MutS_V, MutS_II, MutS_I and MutS_IV. The MutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1, 2, 3, 4, 5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein. The aligned region corresponds with domain III, which is central to the structure of Thermus aquaticus MutS.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain III domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 2 hidden Markov models representing the DNA repair protein MutS, domain III superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]