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DNA repair protein MutS, domain III family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DNA repair protein MutS, domain III [ 48333]
Superfamily:   DNA repair protein MutS, domain III [ 48334]
Family:   DNA repair protein MutS, domain III [ 48335]


Family statistics
Genomes (2,119) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,156 17,646 8
Proteins 2,156 17,646 8


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.2236Least InformativeInherited
Disease Ontology (DO)urinary system cancer0.0006213InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.1429Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1811Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1999Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Neoplasm0.01007Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.01534Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.03709Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.000002356InformativeDirect
Phenotypic Abnormality (PA)Neoplasm by histology0.00033InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.0006249InformativeDirect
Phenotypic Abnormality (PA)Abnormal intestine morphology0.003665InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.04402InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the uterus0.06206InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1101InformativeInherited
Phenotypic Abnormality (PA)Endometrial carcinoma0.00000002241Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the astrocytes0.0000000281Highly InformativeDirect
Phenotypic Abnormality (PA)Glioma0.0000002384Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the rectum0.0000002696Highly InformativeDirect
Phenotypic Abnormality (PA)Colon cancer0.0000003048Highly InformativeDirect
Phenotypic Abnormality (PA)Intestinal polyposis0.0000008501Highly InformativeDirect
Phenotypic Abnormality (PA)Neoplasm of the thyroid gland0.000001904Highly InformativeDirect
Phenotypic Abnormality (PA)Ovarian neoplasm0.000002198Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the stomach0.001399Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system morphology0.0006266Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin morphology0.004529Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.005016Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.007108Moderately InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.0001154InformativeDirect
Mammalian Phenotype (MP)increased malignant tumor incidence0.0002977InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.001439InformativeInherited
Mammalian Phenotype (MP)increased skin tumor incidence0.000001678Highly InformativeDirect
Mammalian Phenotype (MP)increased alimentary system tumor incidence0.000006483Highly InformativeDirect
Mammalian Phenotype (MP)abnormal DNA repair0.00001857Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.00002117Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.007349Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000559Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0006386Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.01872Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.04989Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)testis0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 2 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DNA repair protein MutS, domain III domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]