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GTPase activation domain, GAP superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Families:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)
  p120GAP domain-like [ 48360] (2)


Superfamily statistics
Genomes (514) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,816 48,099 10
Proteins 15,662 47,808 10


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.364Moderately InformativeInherited
Disease Ontology (DO)bone marrow disease0.0006225Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0001087InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1178Least InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.0291Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1343Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cerebellum morphology0.1132InformativeInherited
Mammalian Phenotype (MP)ectopic cerebellar granule cells0.000002276Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.000000004496Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000000006811Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000003075Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.007726Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.007757Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3227Least InformativeInherited
Worm Phenotype (WP)neuron development variant0.00000001848Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.00001064Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.00005511Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.06054Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.6846Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.000000000000002228InformativeDirect
Worm Phenotype (WP)neuron morphology variant0.00003797InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.000611InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.001624InformativeInherited
Worm Phenotype (WP)cell component localization variant0.1791InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.2096InformativeInherited
Worm Phenotype (WP)muscle cell attachment variant0.000007011Highly InformativeDirect
Worm Phenotype (WP)axon branching variant0.0000135Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective0.00007625Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.00367Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.4857Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6151Least InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.2523Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.8568Moderately InformativeInherited
Zebrafish Anatomy (ZA)primary germ layer0.06553InformativeInherited
Zebrafish Anatomy (ZA)neuron0.09194InformativeInherited
Zebrafish Anatomy (ZA)primary motor neuron0.0002911Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.004282Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups0.007597Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000003734Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000004831Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000009776InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008936 SSF48350 Protein matches
Abstract

Proteins containing a RhoGAP (Rho GTPase Activating Protein) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho, Rac and/or Cdc42, inactivating these regulators of the actin cytoskeleton. The 53 known human RhoGAP domain-containing proteins are the largest known group of Rho GTPase regulators and significantly outnumber the 21 Rho GTPases they presumably regulate. This excess of GAP proteins probably indicates complex regulation of the Rho GTPases and is consistent with the existence of almost as many (48) human Dbl domain-containing Rho GEFs that act antagonistically to the RhoGAP proteins by activating the Rho GTPases. Phylogenetic analysis offers evidence for frequent domain duplication and for duplication of the entire genes containing these GAP domains [PubMed12297274].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 14 hidden Markov models representing the GTPase activation domain, GAP superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]