SUPERFAMILY 1.75 HMM library and genome assignments server

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Phoshoinositide 3-kinase (PI3K) helical domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Family:   Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]


Family statistics
Genomes (160) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 521 1,319 4
Proteins 521 1,319 4


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1896Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000007007InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase5.205e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0148Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.01637Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.04166Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.04523Least InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.000771Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0.002226Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.002769Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.007136Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.008429Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.009694Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.01783Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.06855Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2465Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.2971Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00001578InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.00008813InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0002144InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0.0002671InformativeDirect
Mammalian Phenotype (MP)abnormal sterol level0.0002697InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.0003548InformativeDirect
Mammalian Phenotype (MP)abnormal heart size0.0007022InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal body size0.001466InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.00236InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.003249InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte morphology0.02734InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen level0.00003273Highly InformativeDirect
Mammalian Phenotype (MP)skin lesions0.00004862Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002029Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007526Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number0.0008863Highly InformativeDirect
Mammalian Phenotype (MP)increased granulocyte number0.000965Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)protein expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1647InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]