SUPERFAMILY 1.75 HMM library and genome assignments server

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Ankyrin repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Family:   Ankyrin repeat [ 48404] (17)


Family statistics
Genomes (701) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 15,867 51,808 38
Proteins 12,703 42,457 38


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.3544Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.0886Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0006358Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.0007611Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptid0.0008188Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.8591Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3382Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Pentosyltransferases0.006506InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.0000000000001109Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000001614Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.3955Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.01636Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7151Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1544InformativeInherited
Disease Ontology (DO)skin hemangioma0.000002086Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0004199Highly InformativeDirect
Disease Ontology (DO)primary thrombocytopenia0.0008047Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.3938Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5392Least InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.1753Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.3731Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.396Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5807Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.621Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.36InformativeInherited
Mammalian Phenotype (MP)impaired somite development0.007502Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.9185Least InformativeInherited
Worm Phenotype (WP)movement variant0.04465Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.1224Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.1224Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.1232Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.124Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.1365Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.2379Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.4973Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)body bend variant0.0002344InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.0003968InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.000892InformativeDirect
Worm Phenotype (WP)head movement variant0.0009042InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.001261InformativeInherited
Worm Phenotype (WP)organism stress response variant0.001496InformativeInherited
Worm Phenotype (WP)body posture variant0.001968InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.01923InformativeInherited
Worm Phenotype (WP)directionality variant0.07442InformativeInherited
Worm Phenotype (WP)excretory secretory system development variant0.00001572Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0002761Highly InformativeDirect
Worm Phenotype (WP)fat0.0004011Highly InformativeDirect
Worm Phenotype (WP)negative chemotaxis variant0.03834Highly InformativeInherited
Worm Phenotype (WP)body posture wavelength variant0.3777Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.1095InformativeInherited
Yeast Phenotype (YP)cell cycle progression through the G2/M phase transition0.00004951Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0000001499InformativeDirect
Fly Phenotype (FP)behavior defective0.0005631InformativeDirect
Fly Phenotype (FP)sensory perception defective0.00000001247Highly InformativeDirect
Fly Phenotype (FP)chemosensitive behavior defective0.0007011Highly InformativeDirect
Fly Phenotype (FP)temperature response defective0.002461Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.03548Least InformativeInherited
Fly Anatomy (FA)nervous system0.1457Least InformativeInherited
Fly Anatomy (FA)adult0.2158Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.291Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3527Least InformativeInherited
Fly Anatomy (FA)larva0.4652Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.1659Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2444Moderately InformativeInherited
Fly Anatomy (FA)sensory organ cell0.0188InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.4624InformativeInherited
Fly Anatomy (FA)mechanosensory system0.616InformativeInherited
Fly Anatomy (FA)mechanosensory system neuron0.06689Highly InformativeInherited
Fly Anatomy (FA)larval multidendritic neuron0.06689Highly InformativeInherited
Fly Anatomy (FA)sensory cluster0.1643Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.5141Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.5503Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.6361Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3805Moderately InformativeInherited
Zebrafish Anatomy (ZA)ventricular system0.04932Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.0008977Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.394Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.002763Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.03569Moderately InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.3484Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.8942Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000000002441InformativeDirect
Enzyme Commission (EC)In linear amides0.00004009InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.007099InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0.01157InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1InformativeInherited
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.000001264Highly InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000001791Highly InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00002142Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]