SUPERFAMILY 1.75 HMM library and genome assignments server

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14-3-3 protein family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   14-3-3 protein [ 48445]
Family:   14-3-3 protein [ 48446] (4)


Family statistics
Genomes (500) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,675 7,011 8
Proteins 2,647 6,930 8


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system cancer0Moderately InformativeDirect
Disease Ontology (DO)disease of mental health0.001295Moderately InformativeInherited
Disease Ontology (DO)meningioma0InformativeDirect
Disease Ontology (DO)schizophrenia0.00004946InformativeDirect

Document: DO annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)protein expression variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0Moderately InformativeDirect
Worm Phenotype (WP)dauer arrest variant0InformativeDirect
Worm Phenotype (WP)transgene expression reduced0InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0InformativeDirect
Worm Phenotype (WP)endocytic transport defect0InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0InformativeDirect
Worm Phenotype (WP)enzyme activity reduced0Highly InformativeDirect
Worm Phenotype (WP)shortened life span0Highly InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.08871Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.1035Moderately InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0InformativeDirect
Xenopus ANatomical entity (XAN)eye0InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.0000004153InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00002555InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0002867InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.001056InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.001238InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.002013InformativeInherited
Xenopus ANatomical entity (XAN)ganglion0.000002424Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.00002564Highly InformativeDirect
Xenopus ANatomical entity (XAN)fin0.0003097Highly InformativeDirect
Xenopus ANatomical entity (XAN)thymus0.0007255Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0008868Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0000003016InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details) Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 15 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a 14-3-3 protein domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]