SUPERFAMILY 1.75 HMM library and genome assignments server

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Tetratricopeptide repeat (TPR) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Family:   Tetratricopeptide repeat (TPR) [ 48453] (17)


Family statistics
Genomes (860) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,602 14,142 31
Proteins 4,389 13,434 30


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.06133Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.2061Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00001861Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.03783Moderately InformativeInherited
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000006512InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.000113InformativeDirect
Enzyme Commission (EC)Cis-trans Isomerases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.5535Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.1955InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.00002622Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.03257Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.08792Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.178Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.2538Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5775Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8586Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.02849Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.04019Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.1041Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.1938Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.2131Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4629Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.0383InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.4267InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.4429InformativeInherited
Phenotypic Abnormality (PA)Bronchitis0.007317Highly InformativeInherited
Phenotypic Abnormality (PA)Polydactyly0.06458Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.567Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1579Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.05089InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule epithelium morphology0.009465Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.0003452Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.01381Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.01381Least InformativeInherited
Worm Phenotype (WP)cell development variant0.1501Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.01502Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.04377Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.04377Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.04403Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.04429Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.04827Moderately InformativeInherited
Worm Phenotype (WP)germ cell development variant0.1113Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4901Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0004581InformativeDirect
Worm Phenotype (WP)cell cycle arrest0.0002914Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.05508Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.08861Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.1319Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1755Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3517Least InformativeInherited
Zebrafish Anatomy (ZA)cell1Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1235Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.4794Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.9052Moderately InformativeInherited
Zebrafish Anatomy (ZA)head1Moderately InformativeInherited
Zebrafish Anatomy (ZA)pleuroperitoneal region0.02088InformativeInherited
Zebrafish Anatomy (ZA)retina0.2027InformativeInherited
Zebrafish Anatomy (ZA)neuron0.9455InformativeInherited
Zebrafish Anatomy (ZA)pronephros0.000981Highly InformativeDirect
Zebrafish Anatomy (ZA)retinal outer nuclear layer0.01294Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal photoreceptor layer0.01672Highly InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.109Highly InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.1208Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.6969Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.1835Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.2893Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.000000000000003637InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000000005727InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000366InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00004001InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00004962InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000000004631Highly InformativeDirect
Enzyme Commission (EC)Cis-trans isomerases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]