SUPERFAMILY 1.75 HMM library and genome assignments server

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PDEase family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HD-domain/PDEase-like [ 109603]
Superfamily:   HD-domain/PDEase-like [ 109604] (5)
Family:   PDEase [ 48548] (6)


Family statistics
Genomes (349) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,484 10,832 26
Proteins 3,452 10,802 26


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.479Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.06012Moderately InformativeInherited
Disease Ontology (DO)lymphoblastic leukemia0.0004162InformativeDirect
Disease Ontology (DO)chronic lymphocytic leukemia0.000006587Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.2353Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2416Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.02761Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.04389Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0001632InformativeDirect
Phenotypic Abnormality (PA)Abnormality of reproductive system physiology0.0007392InformativeDirect
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.000995InformativeDirect
Phenotypic Abnormality (PA)Hypogonadism0.0001197Highly InformativeDirect
Phenotypic Abnormality (PA)Glucose intolerance0.0001445Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.4048Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.12Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2289Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.307Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01826InformativeInherited
Mammalian Phenotype (MP)decreased neuron number0.04052InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0002067Highly InformativeDirect
Mammalian Phenotype (MP)neurodegeneration0.04139Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.002851Least InformativeInherited
Worm Phenotype (WP)movement variant0.03328Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.2772Moderately InformativeInherited
Worm Phenotype (WP)thermotaxis variant0.000000001333Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect
Fly Phenotype (FP)fertile0Moderately InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 41 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a HD-domain/PDEase-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]