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L-aspartase-like superfamily
SCOP classification
Superfamily statistics
Functional annotation
General category | Metabolism |
Detailed category | Amino acids metabolism and transport |
Document: Function annotation of SCOP domain superfamilies
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: EC annotation of SCOP domains
Human Phenotype (HP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: HP annotation of SCOP domains
Mouse Phenotype (MP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: MP annotation of SCOP domains
Worm Phenotype (WP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: WP annotation of SCOP domains
Yeast Phenotype (YP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: YP annotation of SCOP domains
Xenopus Anatomy (XA) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: XA annotation of SCOP domains
Arabidopsis Plant Ontology (AP) (show details)
Highlighted in gray are those with FDR_all>0.001
Document: AP annotation of SCOP domains
Enzyme Commission (EC) (show details)
Highlighted in gray are those with FDR_all>0.001
| EC term | FDR (all) | IC level | SDEC level | Annotation (direct or inherited) |
Enzyme Commission (EC) | Hydro-lyases | 0 | 1.166 | -- | DIRECT |
Enzyme Commission (EC) | Fumarate hydratase | 0 | 2.651 | -- | DIRECT |
Enzyme Commission (EC) | Histidine ammonia-lyase | 0 | 2.952 | -- | DIRECT |
Enzyme Commission (EC) | Argininosuccinate lyase | 0 | 2.952 | -- | DIRECT |
Enzyme Commission (EC) | Tyrosine 2,3-aminomutase | 0.00000000001956 | 2.952 | -- | DIRECT |
Enzyme Commission (EC) | 3-carboxy-cis,cis-muconate cycloisomerase | 0.000000000056 | 2.952 | -- | DIRECT |
Enzyme Commission (EC) | Phenylalanine aminomutase (L-beta-phenylalanine forming) | 0.00000007914 | 2.952 | -- | DIRECT |
Enzyme Commission (EC) | Adenylosuccinate lyase | 0.0000006083 | 2.952 | -- | DIRECT |
Enzyme Commission (EC) | Phenylalanine ammonia-lyase | 0.000001466 | 2.952 | -- | DIRECT |
Enzyme Commission (EC) | Intramolecular lyases | 0.003213 | 1.952 | -- | INHERITED FROM: 3-carboxy-cis,cis-muconate cycloisomerase |
Enzyme Commission (EC) | Transferring amino groups | 0.005582 | 2.475 | -- | INHERITED FROM: Tyrosine 2,3-aminomutase || Phenylalanine aminomutase (L-beta-phenylalanine forming) |
Enzyme Commission (EC) | Lyases | 0 | 0.6918 | Least Informative | DIRECT |
Enzyme Commission (EC) | Carbon-oxygen lyases | 1 | 1.012 | Moderately Informative | INHERITED FROM: Fumarate hydratase || Hydro-lyases |
Enzyme Commission (EC) | Isomerases | 1 | 0.8446 | Moderately Informative | INHERITED FROM: Phenylalanine aminomutase (L-beta-phenylalanine forming) || Tyrosine 2,3-aminomutase || 3-carboxy-cis,cis-muconate cycloisomerase |
Enzyme Commission (EC) | Carbon-nitrogen lyases | 0 | 1.673 | Informative | DIRECT |
Enzyme Commission (EC) | Intramolecular transferases | 1 | 1.408 | Informative | INHERITED FROM: Phenylalanine aminomutase (L-beta-phenylalanine forming) || Tyrosine 2,3-aminomutase |
Enzyme Commission (EC) | Ammonia-lyases | 0 | 1.952 | Highly Informative | DIRECT |
Enzyme Commission (EC) | Lyases acting on amides, amidines, etc | 0 | 1.998 | Highly Informative | DIRECT |
Enzyme Commission (EC) | Intramolecular lyases | 1 | 1.952 | Highly Informative | INHERITED FROM: 3-carboxy-cis,cis-muconate cycloisomerase |
Document: EC annotation of SCOP domains
InterPro annotation
Cross references | IPR008948 SSF48557 Protein matches |
Abstract | The enzyme L-aspartate ammonia-lyase (aspartase) catalyses the reversible deamination of the amino acid L-aspartic acid, using a carbanion mechanism to produce fumaric acid and ammonium ion. Aspartases from different organisms show high sequence homology, and this homology extends to functionally related enzymes such as the class II fumarases, the argininosuccinate and adenylosuccinate lyases. The high-resolution structure of aspartase reveals a monomer that is composed of three domains oriented in an elongated S-shape [9230045]. The central domain, comprised of five-helices, provides the subunit contacts in the functionally active tetramer. The active sites are located in clefts between the subunits and structural and mutagenic studies have identified several of the active site functional groups. A separate regulatory site has been identified. The substrate, aspartic acid, can also play the role of an activator, binding at this site along with a required divalent metal ion. |
InterPro database
PDBeMotif information about ligands, sequence and structure motifs
PDBeMotif resource
Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]
Internal database links
Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level.
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Alignments of sequences to 44 models
in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.
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Browse and view proteins in genomes which have
different domain combinations including a L-aspartase-like domain.
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Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
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Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.
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There are 44 hidden Markov models representing the L-aspartase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.
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Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]
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