SUPERFAMILY 1.75 HMM library and genome assignments server

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V set domains (antibody variable domain-like) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Family:   V set domains (antibody variable domain-like) [ 48727] (32)


Family statistics
Genomes (65) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,466 13,107 1,016
Proteins 5,407 12,803 1,003


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.4682Least InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01126Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.08274Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.1188Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.00003029InformativeDirect
Disease Ontology (DO)cholangitis0.0006082Highly InformativeDirect
Disease Ontology (DO)leukocyte disease0.07594Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.3638Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.7179Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.9497Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2441Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2941Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.3752Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.01908InformativeInherited
Phenotypic Abnormality (PA)Skin plaque0.000006342Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal lymphocyte morphology0.00007718Highly InformativeDirect
Phenotypic Abnormality (PA)Syncope0.0006813Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.0000002351Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000005927Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.3105Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype1Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1486Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.2494Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.303Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3766Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.4253Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.4895Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.5722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.9266Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00003806InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0001324InformativeDirect
Mammalian Phenotype (MP)abnormal pancreas physiology0.01799InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.2728InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.3397InformativeInherited
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.5181InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.5817InformativeInherited
Mammalian Phenotype (MP)abnormal T cell proliferation0.000006559Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myelination0.0003106Highly InformativeDirect
Mammalian Phenotype (MP)decreased IgG level0.1686Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]