SUPERFAMILY 1.75 HMM library and genome assignments server

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C1 set domains (antibody constant domain-like) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Family:   C1 set domains (antibody constant domain-like) [ 48942] (23)


Family statistics
Genomes (50) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,954 23,383 988
Proteins 2,739 22,744 954


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.008057Least InformativeInherited
Disease Ontology (DO)organ system cancer0.1708Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000001975Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0000001644Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.000003199Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00001823Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.00002395Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.0002952Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.0009343Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.00292Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03188Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.03351Moderately InformativeInherited
Disease Ontology (DO)syndrome0.1674Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000006131InformativeDirect
Disease Ontology (DO)liver disease0.00000002503InformativeDirect
Disease Ontology (DO)Kawasaki disease0.0000001129InformativeDirect
Disease Ontology (DO)vasculitis0.00003333InformativeDirect
Disease Ontology (DO)hypotrichosis0.00004805InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0003129InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0003588InformativeDirect
Disease Ontology (DO)arthropathy0.01104InformativeInherited
Disease Ontology (DO)bullous skin disease0.01245InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.04475InformativeInherited
Disease Ontology (DO)eye disease0.06102InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)Graves' disease0.00000000007061Highly InformativeDirect
Disease Ontology (DO)psoriatic arthritis0.0000003861Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.0000009922Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.000001341Highly InformativeDirect
Disease Ontology (DO)hemochromatosis0.0000018Highly InformativeDirect
Disease Ontology (DO)spondylitis0.000008751Highly InformativeDirect
Disease Ontology (DO)neuromyelitis optica0.00001489Highly InformativeDirect
Disease Ontology (DO)pemphigus0.00001789Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.00002391Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.00003804Highly InformativeDirect
Disease Ontology (DO)vascular hemostatic disease0.00007335Highly InformativeDirect
Disease Ontology (DO)uveitis0.0001274Highly InformativeDirect
Disease Ontology (DO)rheumatic fever0.0002952Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0008331Highly InformativeDirect
Disease Ontology (DO)thyroid gland disease0.001791Highly InformativeInherited
Disease Ontology (DO)neuromuscular disease0.02601Highly InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.4258Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.00000000216InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.00001626Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.006884Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07436Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.08015Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1907Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2029Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2731Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3199Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3201Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.5423Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.002006Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.002975Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.008371Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.01358Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.05148Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.05777Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.07334Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.07749Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.1175Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1379Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.1767Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2157Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.2876Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4277Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.4328Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.445Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.5125Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.5287Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.5362Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.000004436InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.00002266InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0.000128InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0001755InformativeDirect
Phenotypic Abnormality (PA)Abnormal intestine morphology0.0004163InformativeDirect
Phenotypic Abnormality (PA)Recurrent infections0.0004738InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.001071InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.02284InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.03056InformativeInherited
Phenotypic Abnormality (PA)Stomatitis0.03198InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.2319InformativeInherited
Phenotypic Abnormality (PA)Pain0.2811InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.3624InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.3939InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5772InformativeInherited
Phenotypic Abnormality (PA)Arthralgia0.000000246Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.000001278Highly InformativeDirect
Phenotypic Abnormality (PA)Pericarditis0.000004725Highly InformativeDirect
Phenotypic Abnormality (PA)Cough0.00001618Highly InformativeDirect
Phenotypic Abnormality (PA)Bronchiectasis0.0001058Highly InformativeDirect
Phenotypic Abnormality (PA)Skin ulcer0.0001506Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.0001688Highly InformativeDirect
Phenotypic Abnormality (PA)Glomerulopathy0.0002528Highly InformativeDirect
Phenotypic Abnormality (PA)Alopecia0.0002626Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal sputum0.0004641Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.0005411Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pleura0.0005728Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.0005757Highly InformativeDirect
Phenotypic Abnormality (PA)Diabetes insipidus0.0006282Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pancreas physiology0.0006641Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.0006777Highly InformativeDirect
Phenotypic Abnormality (PA)Chest pain0.000703Highly InformativeDirect
Phenotypic Abnormality (PA)Otitis media0.1457Highly InformativeInherited
Phenotypic Abnormality (PA)Conjunctivitis0.2209Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of facial skeleton0.2848Highly InformativeInherited
Phenotypic Abnormality (PA)Keratitis0.3179Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00000008025Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.4384Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00000003327Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.00004676Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.02564Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.03708Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1786Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.1981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3192Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.6649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.0000008271InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.0001291InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.0005197InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.03999InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2763InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.2815InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.327InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.5417InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.00000146Highly InformativeDirect
Mammalian Phenotype (MP)enhanced paired-pulse facilitation0.00006664Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0.2627Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]