SUPERFAMILY 1.75 HMM library and genome assignments server

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I set domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Family:   I set domains [ 49159] (38)


Family statistics
Genomes (81) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,969 13,306 162
Proteins 3,085 8,095 101


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0000006059Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.002937Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00001477InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000003677Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4727Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.04039Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.1456Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.3092Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.7992Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.853Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.01989InformativeInherited
Disease Ontology (DO)lymphoma0.1161InformativeInherited
Disease Ontology (DO)mature T-cell and NK-cell lymphoma0.0007087Highly InformativeDirect
Disease Ontology (DO)synostosis0.002116Highly InformativeInherited
Disease Ontology (DO)kidney failure0.1286Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.07821Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4817Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6156Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7241Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.1542Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2071Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.3702Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3778Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4105Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.7512Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual infection0.7657Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.2519InformativeInherited
Phenotypic Abnormality (PA)Recurrent infections0.291InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.3599InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.3801InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.3893InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.4299InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.8368InformativeInherited
Phenotypic Abnormality (PA)Corneal erosion0.009452Highly InformativeInherited
Phenotypic Abnormality (PA)Otitis media0.01688Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.1263Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the phalanges of the hand0.1832Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the feet0.3014Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01311Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.07173Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1452Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.4131Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.7341Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9092Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.0004983Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal head morphology0.03686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.03805Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.04846Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.06263Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.1412Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2244Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.2508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.4413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.4799Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.8061Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.8643Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.8711Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.0009625InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.03372InformativeInherited
Mammalian Phenotype (MP)abnormal neurite morphology0.2119InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.4228InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.5026InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.5213InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.6999InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.8535InformativeInherited
Mammalian Phenotype (MP)abnormal urothelium morphology0.0006608Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.0599Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.1877Highly InformativeInherited
Mammalian Phenotype (MP)abnormal uterus morphology0.3345Highly InformativeInherited
Mammalian Phenotype (MP)abnormal axon morphology0.3397Highly InformativeInherited
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.3973Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00000122Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0008403Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0009492Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.02144Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.02144Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3027Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.00006718Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00007537Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0001576Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001576Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0001589Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0001602Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0001806Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01981Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.02493Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.03805Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.2352Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.521Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.000001397InformativeDirect
Worm Phenotype (WP)tail morphology variant0.00007769InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001039InformativeDirect
Worm Phenotype (WP)body posture variant0.0001065InformativeDirect
Worm Phenotype (WP)vulva morphology variant0.0002778InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.003042InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.008782InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.01873InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.03671InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04522InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.05035InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.06449InformativeInherited
Worm Phenotype (WP)drug resistant0.07517InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.08258InformativeInherited
Worm Phenotype (WP)neuron migration variant0.115InformativeInherited
Worm Phenotype (WP)cell component localization variant0.3223InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.0000000001224Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000000001831Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000004145Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00001131Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.00001518Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00001611Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.00004634Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00006227Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.0004584Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0005025Highly InformativeDirect
Worm Phenotype (WP)cell polarity variant0.0009163Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0183Highly InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor resistant0.01961Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.05476Highly InformativeInherited
Worm Phenotype (WP)pausing variant0.1997Highly InformativeInherited
Worm Phenotype (WP)neurite development variant0.2541Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.3158Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.00004295Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.009794Least InformativeInherited
Fly Anatomy (FA)tagma0.03828Least InformativeInherited
Fly Anatomy (FA)nervous system0.07094Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.0863Least InformativeInherited
Fly Anatomy (FA)adult0.1266Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1278Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1452Least InformativeInherited
Fly Anatomy (FA)segment0.2048Least InformativeInherited
Fly Anatomy (FA)larva0.2386Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00002758Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.001394Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.002011Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.006107Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.006263Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.01135Moderately InformativeInherited
Fly Anatomy (FA)neuron0.08843Moderately InformativeInherited
Fly Anatomy (FA)adult head0.2335Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.2842Moderately InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.0005271InformativeDirect
Fly Anatomy (FA)segmental subdivision of organ system0.0006236InformativeDirect
Fly Anatomy (FA)primordium0.001711InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.003073InformativeInherited
Fly Anatomy (FA)syncytium0.003223InformativeInherited
Fly Anatomy (FA)brain0.003388InformativeInherited
Fly Anatomy (FA)adult central nervous system0.005181InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.005808InformativeInherited
Fly Anatomy (FA)muscle cell0.00708InformativeInherited
Fly Anatomy (FA)sensory organ cell0.01142InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.01604InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01633InformativeInherited
Fly Anatomy (FA)chemosensory system0.01842InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.05026InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.05054InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.05706InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1497InformativeInherited
Fly Anatomy (FA)mechanosensory system0.2945InformativeInherited
Fly Anatomy (FA)tract0.3326InformativeInherited
Fly Anatomy (FA)s-LNv neuron0.00000006197Highly InformativeDirect
Fly Anatomy (FA)embryonic heart cardioblast0.000001355Highly InformativeDirect
Fly Anatomy (FA)connective0.00004308Highly InformativeDirect
Fly Anatomy (FA)gustatory receptor neuron0.00006361Highly InformativeDirect
Fly Anatomy (FA)commissure0.0002675Highly InformativeDirect
Fly Anatomy (FA)visceral mesoderm derivative0.0007023Highly InformativeDirect
Fly Anatomy (FA)mechanosensory system neuron0.0008477Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.01732Highly InformativeInherited
Fly Anatomy (FA)early extended germ band embryo0.03118Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.06162Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.7157Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7484Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.1481Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.1187InformativeInherited
Zebrafish Anatomy (ZA)white matter0.000009074Highly InformativeDirect
Zebrafish Anatomy (ZA)synencephalon0.00009917Highly InformativeDirect
Zebrafish Anatomy (ZA)brainstem0.007302Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3417Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4225Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.4737Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.4934Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.902Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.001077Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.007698Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.7473Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.00008038InformativeDirect
Xenopus ANatomical entity (XAN)eye0.002771InformativeInherited
Xenopus ANatomical entity (XAN)pharyngeal region0.004781InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.005617InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.00001527Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.00003577Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.000847Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.03132Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.7435Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.00000049Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0002214InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.00001854Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]