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Fibronectin type III family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Family:   Fibronectin type III [ 49266] (44)


Family statistics
Genomes (178) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,788 25,820 172
Proteins 5,142 15,784 117


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000001381Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004123Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2382Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002342Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5427Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2379Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.457Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.6443Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.01628Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.0102Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2504Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6647Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6907Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9116Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004784Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01864Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.07527Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1158Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2284Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7769Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.8872Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.9097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.9165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.02878InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1119InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3772InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.5473InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8314InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0002532Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.0003461Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.06434Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00004197Least InformativeDirect
Worm Phenotype (WP)cell development variant0.008148Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.02199Least InformativeInherited
Worm Phenotype (WP)movement variant0.000003754Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.00000404Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.01702Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.05595Moderately InformativeInherited
Worm Phenotype (WP)locomotion reduced0.0000406InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001605InformativeDirect
Worm Phenotype (WP)body posture variant0.0005826InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.002355InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.008745InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.04199InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.0000000003754Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00000002637Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.0001165Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.7097Highly InformativeInherited
Worm Phenotype (WP)axon morphology variant0.7288Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0006876Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001546Least InformativeInherited
Fly Anatomy (FA)tagma0.00963Least InformativeInherited
Fly Anatomy (FA)nervous system0.01612Least InformativeInherited
Fly Anatomy (FA)adult0.0398Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.0584Least InformativeInherited
Fly Anatomy (FA)segment0.05905Least InformativeInherited
Fly Anatomy (FA)larva0.1366Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3176Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.000000002872Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0.001038Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.002079Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.006107Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.0159Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03407Moderately InformativeInherited
Fly Anatomy (FA)neuron0.236Moderately InformativeInherited
Fly Anatomy (FA)adult head0.4556Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.471Moderately InformativeInherited
Fly Anatomy (FA)nerve0.0008775InformativeDirect
Fly Anatomy (FA)synaptic neuropil block0.001986InformativeInherited
Fly Anatomy (FA)segmental subdivision of organ system0.00822InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.02458InformativeInherited
Fly Anatomy (FA)primordium0.02521InformativeInherited
Fly Anatomy (FA)chemosensory system0.03075InformativeInherited
Fly Anatomy (FA)brain0.03257InformativeInherited
Fly Anatomy (FA)labral segment0.04697InformativeInherited
Fly Anatomy (FA)adult central nervous system0.0763InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.1109InformativeInherited
Fly Anatomy (FA)tract0.4146InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.5411InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.6884InformativeInherited
Fly Anatomy (FA)s-LNv neuron0.00000005038Highly InformativeDirect
Fly Anatomy (FA)commissure0.000004947Highly InformativeDirect
Fly Anatomy (FA)embryonic heart cardioblast0.00004923Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0002273Highly InformativeDirect
Fly Anatomy (FA)gustatory receptor neuron0.0007538Highly InformativeDirect
Fly Anatomy (FA)adult protocerebrum0.3809Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.203Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.6078Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6619Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.323Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.6898Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.09453InformativeInherited
Zebrafish Anatomy (ZA)white matter0.0000003985Highly InformativeDirect
Zebrafish Anatomy (ZA)synencephalon0.0003282Highly InformativeDirect
Zebrafish Anatomy (ZA)brainstem0.001594Highly InformativeInherited
Zebrafish Anatomy (ZA)telencephalon0.1859Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.6274Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8447Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9458Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1715Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.3297Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.332InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0001931Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0009855Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000005678Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000007138Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.000000000000004353Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00008083Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.9473Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000106InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1942InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.8271InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 169 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]