SUPERFAMILY 1.75 HMM library and genome assignments server

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Cadherin family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Cadherin-like [ 49313] (2)
Family:   Cadherin [ 49314] (3)

Family statistics
Genomes (66) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,124 2,760 26
Proteins 513 1,242 13

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)integumentary system disease0.01604Moderately InformativeInherited
Disease Ontology (DO)hypotrichosis0.0009003InformativeDirect
Disease Ontology (DO)bullous skin disease0.00352InformativeInherited
Disease Ontology (DO)pemphigus0.00002412Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.6314Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9145Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.4018Moderately InformativeInherited
Phenotypic Abnormality (PA)Arrhythmia0.1347InformativeInherited
Phenotypic Abnormality (PA)Abnormal jaw morphology0.2965Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2025Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7609Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.0739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1823Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.2075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.3515Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.0008453InformativeDirect
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.05779InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.2486InformativeInherited
Mammalian Phenotype (MP)abnormal orientation of cochlear hair cell stereociliary bundles0.000001162Highly InformativeDirect
Mammalian Phenotype (MP)abnormal urinary system development0.0004676Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.02451Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.1581Moderately InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.3941InformativeInherited
Worm Phenotype (WP)cell polarity variant0.0000008319Highly InformativeDirect
Worm Phenotype (WP)anchor cell invasion variant0.00002854Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001065Highly InformativeDirect
Worm Phenotype (WP)neurite development variant0.03469Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0000003492InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.2932Least InformativeInherited
Fly Anatomy (FA)tagma0.3141Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3517Least InformativeInherited
Fly Anatomy (FA)nervous system0.4765Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.6253Least InformativeInherited
Fly Anatomy (FA)adult0.636Least InformativeInherited
Fly Anatomy (FA)larva0.7676Least InformativeInherited
Fly Anatomy (FA)adult head0.07446Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.09215Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1497Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.191Moderately InformativeInherited
Fly Anatomy (FA)neuron0.4549Moderately InformativeInherited
Fly Anatomy (FA)sensory organ cell0.03032InformativeInherited
Fly Anatomy (FA)histaminergic neuron0.03394InformativeInherited
Fly Anatomy (FA)adult peripheral nervous system0.03419InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.04344InformativeInherited
Fly Anatomy (FA)photoreceptor cell0.0659InformativeInherited
Fly Anatomy (FA)adult head sensillum0.1001InformativeInherited
Fly Anatomy (FA)eye0.2659InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.4068Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6971Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.699Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01098Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.3616Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.01001InformativeInherited
Zebrafish Anatomy (ZA)white matter0.0002356Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.01607Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.3013InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 35 and 360.0009095Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 33 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cadherin-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]