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CBD9-like superfamily
SCOP classification
InterPro annotation
| Cross references | IPR008960 SSF49344 Protein matches |
| Abstract | This entry represents an immunoglobulin-like beta-sandwich domain found in a variety of protein families, including family 9 carbohydrate-binding (CDB9) enzymes like endo-1,4-beta-xylanase , as the C-terminal domain of glucodextranase enzymes , and as the cytochrome domain of cellobiose dehydrogenase enzymes . In general, these domains consist of 7 beta-strands in 2 sheets with a Greek key topology, but with an additional beta-strand at the N-terminus [ 11371186, 12796496].
Bacterial extracellular cellulases and hemicellulases are involved in the hydrolysis of the major structural polysaccharides of plant cell walls. These are usually modular enzymes that contain catalytic and non-catalytic domains. The CBD9 domain binds to cellulose, xylan, as well as to a range of soluble di- and mono-saccharides, and is found in cellulose- and xylan-degrading enzymes [9752722].
Cellobiose dehydrogenases (CDHs) are extracellular hemoflavoenzymes produced by various wood-degrading fungi that are involved in the degradation of cellulose and lignin [10725534]. These enzymes consist of a cytochrome domain and a flavin domain, which are believed to have evolved in parallel as fused genes, because the two domains can be cleaved proteolytically to make a functional cytochrome and flavodehydrogenase [10673428]. The b-type cytochrome domain contains a 6-coordinate low spin b-type haem with unusual iron ligands and coordination geometry.
Glucodextranase hydrolyzes alpha-1,6-glucosidic linkages of dextran from the non-reducing end to produce beta-D-glucose via an inverting reaction mechanism and classified into the glycoside hydrolase family 15 (GH15) [14660574]. |
InterPro database
Functional annotation
| General category | Other |
| Detailed category | Unknown function |
Function annotation of SCOP domain superfamilies
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Internal database links
The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments'
icon above to view the genome assignments for this superfamily.
Alignments of sequences to Alignments of sequences to 3 models
in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.
It is possible to browse and view the proteins in the genomes which have
different combinations of domains including a CBD9-like domain. Click on the 'Domain Combinations' icon.
To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.
There are 3 hidden Markov models representing the CBD9-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.
Jump to [ Top of page · SCOP classification · InterPro annotation · Functional annotation · Internal database links ]
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