SUPERFAMILY 1.75 HMM library and genome assignments server

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Alpha-macroglobulin receptor domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   Alpha-macroglobulin receptor domain [ 49410]
Family:   Alpha-macroglobulin receptor domain [ 49411] (2)

Family statistics
Genomes (55) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 252 565 3
Proteins 251 559 3

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.04111Least InformativeInherited
Disease Ontology (DO)urinary system disease0.005606Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.008837Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.0258Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.05041Moderately InformativeInherited
Disease Ontology (DO)periodontal disease0.00007447InformativeDirect
Disease Ontology (DO)psoriasis0.0001899InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0009514InformativeDirect
Disease Ontology (DO)proteinuria0.00000524Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.09616Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3703Least InformativeInherited
Phenotypic Abnormality (PA)Unusual infection0.00306Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.0000000712InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.008849InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.006511Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1815Least InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.00003646Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0006528Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.004622Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.006415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.06919Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.0000652InformativeDirect
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.0001248InformativeDirect
Mammalian Phenotype (MP)abnormal placenta morphology0.00101InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.001081InformativeInherited
Mammalian Phenotype (MP)increased susceptibility to infection0.002585InformativeInherited
Mammalian Phenotype (MP)abnormal trophoblast layer morphology0.0000858Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pregnancy0.00009487Highly InformativeDirect
Mammalian Phenotype (MP)abnormal placenta labyrinth morphology0.0001354Highly InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to bacterial infection0.0005042Highly InformativeDirect

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.1209Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.1035Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.2234Moderately InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.0007996InformativeDirect
Xenopus ANatomical entity (XAN)hindgut0.000001023Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0006185Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Alpha-macroglobulin receptor domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]