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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (367) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,320 19,251 53
Proteins 6,210 18,948 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1039Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001444Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.004845Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01041Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.02461Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0000002793InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000002659InformativeDirect
Disease Ontology (DO)connective tissue cancer0.00009388InformativeDirect
Disease Ontology (DO)physical disorder0.001157InformativeInherited
Disease Ontology (DO)lymphoma0.007302InformativeInherited
Disease Ontology (DO)breast cancer0.008723InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01093InformativeInherited
Disease Ontology (DO)respiratory system cancer0.1011InformativeInherited
Disease Ontology (DO)viral infectious disease0.2672InformativeInherited
Disease Ontology (DO)colitis0.00000008815Highly InformativeDirect
Disease Ontology (DO)Burkitt lymphoma0.00002725Highly InformativeDirect
Disease Ontology (DO)mumps0.00006612Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00007318Highly InformativeDirect
Disease Ontology (DO)gastritis0.0002506Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0004027Highly InformativeDirect
Disease Ontology (DO)pertussis0.0004159Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.000514Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005405Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0005584Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0007403Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.00762Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.4163Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6154Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6317Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.164Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1934Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2821Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.001627InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.02682InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.2213InformativeInherited
Phenotypic Abnormality (PA)Anterior hypopituitarism0.0004985Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the thorax0.01671Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.1864Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.00000162Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.000002066Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0002011Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0003394Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.006073Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.00755Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02702Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1983Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.000000009953Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000004967Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000008424Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.000001233Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.00000185Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0000054Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000009519Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000009673Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.0000284Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.00008617Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008547Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001439Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003633Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.005903Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01525Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.0201Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03062Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.03168Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.03405Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.04825Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.05449Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.05837Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.08228Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.1005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1338Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.4832Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7251Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.00000001071InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0000003071InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003194InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00001352InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.00002023InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.00003045InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.00004705InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.00006715InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001193InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0001353InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0003107InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0004411InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0.002034InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.003867InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.004064InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.008822InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.01021InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.01213InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.02273InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.02869InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.04135InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.04154InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07083InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0752InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.07946InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.241InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.2423InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.3272InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.3511InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.381InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.4837InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.5392InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6989InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8938InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000006226Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000009135Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.000009683Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00002643Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00006079Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001099Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001289Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.0001313Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0001554Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001705Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0002122Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0002749Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0003088Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0003215Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0005456Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.0006225Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0006595Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0008635Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0008635Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.008999Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgG2a level0.01024Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.01327Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.01367Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.01873Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.06026Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1246Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.1485Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.2191Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.2649Highly InformativeInherited
Mammalian Phenotype (MP)increased IgG level0.3558Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8425Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.01804Least InformativeInherited
Worm Phenotype (WP)cell development variant0.04864Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.05791Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.2372Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.2376Least InformativeInherited
Worm Phenotype (WP)cell division variant0.05636Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)lineage variant0.0004457Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0005637Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0006435Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0007657Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.002075Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01055Least InformativeInherited
Fly Anatomy (FA)somatic cell0.03877Least InformativeInherited
Fly Anatomy (FA)larva0.107Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)region of integument0.002753Moderately InformativeInherited
Fly Anatomy (FA)thorax0.008416Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.02001Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.02142Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.03095Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.06616Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.0002208InformativeDirect
Fly Anatomy (FA)mechanosensory system0.0002263InformativeDirect
Fly Anatomy (FA)anatomical space0.001983InformativeInherited
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001763Highly InformativeDirect
Fly Anatomy (FA)mesothoracic tergum0.0004359Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.05949Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.03568Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0427Moderately InformativeInherited
Zebrafish Anatomy (ZA)primary germ layer0.00028InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.1306Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2635Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.5669Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9295Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00002548Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0003392Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.002927Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0329Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.7457Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.76Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.7963Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.8759Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.000004311InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00001996InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00002205InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00003394InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0001832InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0002314InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0003708InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.0008835InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.05188InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.1217InformativeInherited
Xenopus ANatomical entity (XAN)limb0.6273InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.811InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.9527InformativeInherited
Xenopus ANatomical entity (XAN)hindlimb0.0002938Highly InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.0003572Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.0004351Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.000851Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0008629Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.001267Highly InformativeInherited
Xenopus ANatomical entity (XAN)branchial arch0.1633Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.785Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.01531Highly InformativeInherited

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]