SUPERFAMILY 1.75 HMM library and genome assignments server

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PLC-like (P variant) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Family:   PLC-like (P variant) [ 49563] (11)


Family statistics
Genomes (100) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,571 4,560 18
Proteins 1,571 4,559 18


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02382Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000001033InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)3.476e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.1807Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.1958Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1789Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.2132Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.5402Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.1391InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.1943InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the tongue0.0002849Highly InformativeDirect
Phenotypic Abnormality (PA)Sarcoma0.01082Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01896Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02319Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3142Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.401Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.002023Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.006107Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.01588Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.05433Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.09667Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1482Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2095Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2948Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3483Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.538Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00002838InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0001138InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001221InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.001588InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.04333InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.09539InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell number0.1972InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.1999InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.7322InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.00002398Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic vesicle number0.00007377Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-2 secretion0.000366Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.003924Highly InformativeInherited
Mammalian Phenotype (MP)abnormal platelet morphology0.2119Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.4506Highly InformativeInherited
Mammalian Phenotype (MP)decreased mature B cell number0.5284Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0001245Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0001245Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0002977Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0004562Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.001531Least InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.00000003715Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.00003361Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.0002258Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.007Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.2456Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.5131Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.8827Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.00000105InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.000003796InformativeDirect
Worm Phenotype (WP)defecation variant0.000005205InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00002282InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.00003526InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001229InformativeDirect
Worm Phenotype (WP)cell stress response variant0.0002838InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0005411InformativeDirect
Worm Phenotype (WP)body bend variant0.0006832InformativeDirect
Worm Phenotype (WP)fat content variant0.0008967InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0009984InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.004279InformativeInherited
Worm Phenotype (WP)drug resistant0.06456InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.1151InformativeInherited
Worm Phenotype (WP)organism stress response variant0.4558InformativeInherited
Worm Phenotype (WP)defecation contraction variant0.0000000000003421Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00000000006529Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.000000001119Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.00000003714Highly InformativeDirect
Worm Phenotype (WP)RNAi response variant0.00000004155Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0000001608Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.00002914Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0003374Highly InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor resistant0.07986Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.0001062InformativeDirect
Fly Phenotype (FP)decreased cell size0.000002525Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.11Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1455Least InformativeInherited
Fly Anatomy (FA)nervous system0.1815Least InformativeInherited
Fly Anatomy (FA)segment0.2413Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2932Least InformativeInherited
Fly Anatomy (FA)adult0.3474Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.4134Least InformativeInherited
Fly Anatomy (FA)tagma0.5969Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.02978Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.06005Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.07632Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1287Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1671Moderately InformativeInherited
Fly Anatomy (FA)mesothoracic tergum0.0006265InformativeDirect
Fly Anatomy (FA)primordium0.03986InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.1024InformativeInherited
Fly Anatomy (FA)imaginal disc0.115InformativeInherited
Fly Anatomy (FA)larval multidendritic neuron0.0012Highly InformativeInherited
Fly Anatomy (FA)sensory cluster0.003988Highly InformativeInherited
Fly Anatomy (FA)eye disc0.02134Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.1782Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.5991InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases0.6821Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.03365Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.2813Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00009202InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.000000000000269Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000001887Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00004377Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]