SUPERFAMILY 1.75 HMM library and genome assignments server

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Synaptotagmin-like (S variant) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Family:   Synaptotagmin-like (S variant) [ 49575] (10)


Family statistics
Genomes (196) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,966 8,159 19
Proteins 2,256 6,247 17


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.6586Moderately InformativeInherited
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.2301Least InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.004642Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.9246Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal miniature endplate potential0.0001944Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic vesicle number0.0008622Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.001693Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.0322Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.6285Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.005583Moderately InformativeInherited
Worm Phenotype (WP)protein expression variant0.007308Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.185Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.185Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.1855Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.186Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.1933Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.2631Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.9174Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant1Moderately InformativeInherited
Worm Phenotype (WP)defecation variant0.00000007521InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.000001101InformativeDirect
Worm Phenotype (WP)drug resistant0.000008783InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.00005246InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0009048InformativeDirect
Worm Phenotype (WP)defecation contraction variant6.282e-16Highly InformativeDirect
Worm Phenotype (WP)acetylcholinesterase inhibitor resistant0.0000001534Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping irregular0.0003246Highly InformativeDirect
Worm Phenotype (WP)pharyngeal pumping rate variant0.000558Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0005891Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)neurophysiology defective0.0009769InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0000000000008375Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.5214Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]