SUPERFAMILY 1.75 HMM library and genome assignments server

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Crystallins/Ca-binding development proteins family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   gamma-Crystallin-like [ 49694]
Superfamily:   gamma-Crystallin-like [ 49695] (6)
Family:   Crystallins/Ca-binding development proteins [ 49696] (4)


Family statistics
Genomes (68) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,303 2,528 24
Proteins 1,249 2,460 23


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.00001212Least InformativeDirect
Disease Ontology (DO)eye disease0.0000000001483InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal eye physiology0.7616Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lens0InformativeDirect
Phenotypic Abnormality (PA)Abnormal uvea morphology0.05427InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.6233InformativeInherited
Phenotypic Abnormality (PA)Cataract0Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal dystrophy0.00000008539Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal opacity0.00003317Highly InformativeDirect
Phenotypic Abnormality (PA)Ocular anterior segment dysgenesis0.0001441Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of refraction0.0002548Highly InformativeDirect
Phenotypic Abnormality (PA)Coloboma0.001274Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality iris morphology0.1404Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye morphology0.0000004792Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.00000000001053InformativeDirect
Mammalian Phenotype (MP)abnormal lens morphology0.00000000000005498Highly InformativeDirect
Mammalian Phenotype (MP)microphthalmia0.000002532Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.1178Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)head0.5855Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7877Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.9586Least InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.02488Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.03852Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.01926InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.236Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.1086Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.05121InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.000003768Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a gamma-Crystallin-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]