SUPERFAMILY 1.75 HMM library and genome assignments server

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TNF-like family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   TNF-like [ 49841]
Superfamily:   TNF-like [ 49842]
Family:   TNF-like [ 49843] (14)

Family statistics
Genomes (66) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,396 3,706 40
Proteins 1,396 3,700 40

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.09808Least InformativeInherited
Disease Ontology (DO)organ system cancer0.5504Least InformativeInherited
Disease Ontology (DO)connective tissue disease0.0000000002688Moderately InformativeDirect
Disease Ontology (DO)artery disease0.0001011Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.0002163Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0002752Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.004826Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.006097Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.007357Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.2284Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3834Moderately InformativeInherited
Disease Ontology (DO)atherosclerosis0.000001768InformativeDirect
Disease Ontology (DO)arthritis0.000001906InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.000002044InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.00002312InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0000442InformativeDirect
Disease Ontology (DO)scleroderma0.0005815InformativeDirect
Disease Ontology (DO)hypotrichosis0.0006467InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0007782InformativeDirect
Disease Ontology (DO)Kawasaki disease0.0007944InformativeDirect
Disease Ontology (DO)eye disease0.005535InformativeInherited
Disease Ontology (DO)bullous skin disease0.02795InformativeInherited
Disease Ontology (DO)pancreas disease0.04101InformativeInherited
Disease Ontology (DO)heart disease0.07383InformativeInherited
Disease Ontology (DO)lymphoma0.1131InformativeInherited
Disease Ontology (DO)coronary artery disease0.1483InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis0.00000009587Highly InformativeDirect
Disease Ontology (DO)pemphigus0.00001513Highly InformativeDirect
Disease Ontology (DO)primary open angle glaucoma0.00002444Highly InformativeDirect
Disease Ontology (DO)dilated cardiomyopathy0.00003039Highly InformativeDirect
Disease Ontology (DO)thrombocytopenia0.0005121Highly InformativeDirect
Disease Ontology (DO)meningitis0.0006985Highly InformativeDirect
Disease Ontology (DO)lipid storage disease0.001064Highly InformativeInherited
Disease Ontology (DO)endocrine pancreas disease0.02789Highly InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.06948Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.006403Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1189Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2787Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.9672Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.05765Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual infection0.1519Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.2149Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.3133Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4528Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.00006245InformativeDirect
Phenotypic Abnormality (PA)Recurrent infections0.0008272InformativeDirect
Phenotypic Abnormality (PA)Abnormal cellular physiology0.0289InformativeInherited
Phenotypic Abnormality (PA)Abnormality of complement system0.08361InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.1011InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.235InformativeInherited
Phenotypic Abnormality (PA)Nephritis0.0003431Highly InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.002142Highly InformativeInherited
Phenotypic Abnormality (PA)Increased antibody level in blood0.1639Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01259Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.01565Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.3015Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01195Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.03142Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03593Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.1099Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1781Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.538Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.00005073InformativeDirect
Mammalian Phenotype (MP)abnormal lymph node morphology0.0001579InformativeDirect
Mammalian Phenotype (MP)abnormal spleen morphology0.008474InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01376InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.02083InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.0238InformativeInherited
Mammalian Phenotype (MP)abnormal lymph organ size0.2733InformativeInherited
Mammalian Phenotype (MP)abnormal spleen germinal center morphology0.00001813Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.00005706Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0000674Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.001319Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical lymph node morphology0.0616Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.3302Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TNF-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]