SUPERFAMILY 1.75 HMM library and genome assignments server

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SMAD domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Family:   SMAD domain [ 49880] (4)


Family statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 987 3,069 13
Proteins 985 3,053 13


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)urinary system disease0.001217Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01347Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.03912Moderately InformativeInherited
Disease Ontology (DO)glomerulonephritis0.0000019InformativeDirect
Disease Ontology (DO)scleroderma0.0001326InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.09234Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.00794Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.05242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.05684Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.0005874InformativeDirect
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.002811InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.004InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.01964InformativeInherited
Phenotypic Abnormality (PA)Aortic dissection0.0000002494Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.00002943Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0002309Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.004738Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.008769Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.009179Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.0234Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000001515Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.000006928Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.00002061Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.00002988Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.00005919Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0001253Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.0007287Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.009364Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1176Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3035Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.000001094InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.000002106InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.00002691InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0002268InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.0005268InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.001005InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.009125InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.04124InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.1759InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.2762InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal body size0.3068InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8188InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal axis patterning0.00000001861Highly InformativeDirect
Mammalian Phenotype (MP)abnormal follicle stimulating hormone level0.0000003117Highly InformativeDirect
Mammalian Phenotype (MP)increased reproductive system tumor incidence0.000002581Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.000003421Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.00000769Highly InformativeDirect
Mammalian Phenotype (MP)abnormal chorioallantoic fusion0.00001316Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovarian folliculogenesis0.00002986Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.00003581Highly InformativeDirect
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.00003978Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0005147Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0005665Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system development0.0006259Highly InformativeDirect
Mammalian Phenotype (MP)internal hemorrhage0.001562Highly InformativeInherited
Mammalian Phenotype (MP)increased alimentary system tumor incidence0.01125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal oogenesis0.04987Highly InformativeInherited
Mammalian Phenotype (MP)abnormal female germ cell morphology0.05191Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0003465Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0007771Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.004173Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0000159Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0000659Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000659Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.00006627Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.00006664Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.00007273Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.003091Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.03247Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.04182Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.5131Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.8087Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0000002913InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.000001448InformativeDirect
Worm Phenotype (WP)tail morphology variant0.00002765InformativeDirect
Worm Phenotype (WP)male morphology variant0.00003371InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.00004655InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.00006124InformativeDirect
Worm Phenotype (WP)head movement variant0.00007274InformativeDirect
Worm Phenotype (WP)directionality variant0.0001125InformativeDirect
Worm Phenotype (WP)fat content variant0.0001359InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0001538InformativeDirect
Worm Phenotype (WP)body bend variant0.000166InformativeDirect
Worm Phenotype (WP)body posture variant0.003507InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.01278InformativeInherited
Worm Phenotype (WP)RNA expression variant0.01731InformativeInherited
Worm Phenotype (WP)small0.08594InformativeInherited
Worm Phenotype (WP)social behavior variant0.0000008863Highly InformativeDirect
Worm Phenotype (WP)dauer formation variant0.000001108Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant0.000001653Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.000003968Highly InformativeDirect
Worm Phenotype (WP)short0.0000111Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.00001869Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.00002106Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.00003734Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.00003829Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00003829Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.00007578Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.00008064Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0002477Highly InformativeDirect
Worm Phenotype (WP)male ray morphology variant0.08545Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)decreased cell number0.00001685InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.000008901Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)segment0.07877Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1465Least InformativeInherited
Fly Anatomy (FA)tagma0.2344Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.2517Least InformativeInherited
Fly Anatomy (FA)adult0.2577Least InformativeInherited
Fly Anatomy (FA)abdomen0.001418Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.008898Moderately InformativeInherited
Fly Anatomy (FA)appendage0.01619Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.01676Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.01843Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.02329Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.02435Moderately InformativeInherited
Fly Anatomy (FA)female organism0.0342Moderately InformativeInherited
Fly Anatomy (FA)gonad0.05479Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1208Moderately InformativeInherited
Fly Anatomy (FA)epithelial tube0.0002141InformativeDirect
Fly Anatomy (FA)wing blade0.0002533InformativeDirect
Fly Anatomy (FA)imaginal disc0.001814InformativeInherited
Fly Anatomy (FA)cuticle0.00618InformativeInherited
Fly Anatomy (FA)germline cell0.01863InformativeInherited
Fly Anatomy (FA)female germline stem cell0.00001273Highly InformativeDirect
Fly Anatomy (FA)wing disc0.00009153Highly InformativeDirect
Fly Anatomy (FA)wing vein0.0001373Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.07548Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0.1294Moderately InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.0006378InformativeDirect
Zebrafish Anatomy (ZA)motile cell0.005225InformativeInherited
Zebrafish Anatomy (ZA)immune system0.008654InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.05475InformativeInherited
Zebrafish Anatomy (ZA)floor plate0.0000006652Highly InformativeDirect
Zebrafish Anatomy (ZA)mononuclear phagocyte0.0000322Highly InformativeDirect
Zebrafish Anatomy (ZA)professional antigen presenting cell0.0000414Highly InformativeDirect
Zebrafish Anatomy (ZA)intermediate cell mass of mesoderm0.0001014Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.08596Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail region0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.000129Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.09838Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.0000001388InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00004769InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0008921InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.000922InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.02579InformativeInherited
Xenopus ANatomical entity (XAN)ciliated cell0.000001689Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00008226Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]