SUPERFAMILY 1.75 HMM library and genome assignments server

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FHA domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Family:   FHA domain [ 49885] (11)


Family statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,226 3,947 21
Proteins 1,189 3,874 21


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.09997Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000001563Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000001588Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000000000001689InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0902Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.006076Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03391Moderately InformativeInherited
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.0004942InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0005714InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.01669Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.07419Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1742Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.2396Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6132Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.01861Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0944Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1095Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1182Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3313Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.0003158InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle size0.009858InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.05692InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.07025InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.2825InformativeInherited
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.0001709Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia0.0006784Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal myelination0.005738Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.298Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4189Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.4277Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.5739Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.7834Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.8023Least InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.02332Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.05101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1233Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.1678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1904Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3952Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4071Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.4094Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.001471InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02194InformativeInherited
Mammalian Phenotype (MP)increased gland tumor incidence0.02543InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.03515InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.3155InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.00000421Highly InformativeDirect
Mammalian Phenotype (MP)abnormal DNA repair0.0001003Highly InformativeDirect
Mammalian Phenotype (MP)increased mammary gland tumor incidence0.001695Highly InformativeInherited
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.006425Highly InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.3527Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.122Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.2436Least InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.1049Moderately InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.0008584InformativeDirect
Worm Phenotype (WP)axon morphology variant0.0003636Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant sperm cell0.00003632InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0000356Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0962Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.615Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.00000001233Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.00000005471Moderately InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000002115InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000001027InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0.00006804Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]