SUPERFAMILY 1.75 HMM library and genome assignments server

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SH3-domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   SH3-domain [ 50044]
Family:   SH3-domain [ 50045] (39)


Family statistics
Genomes (194) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,081 15,578 124
Proteins 4,512 13,702 119


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.3399Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0004274Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.9747Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000004983InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.00001669InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0.000000000000004109Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.4598Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.6317Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.09271Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.1729Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.2625Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.5099Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal liver morphology0.3835InformativeInherited
Phenotypic Abnormality (PA)Cellulitis0.00008962Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the stomach0.3796Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01001Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.04371Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.07419Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.7954Least InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.005903Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.05649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.1024Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.1414Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.1798Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1871Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.293Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.3449Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.5237Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.554Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.8015Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.8666Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001503InformativeDirect
Mammalian Phenotype (MP)abnormal cerebral hemisphere morphology0.07202InformativeInherited
Mammalian Phenotype (MP)abnormal limbic system morphology0.1017InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2475InformativeInherited
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.2519InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.2736InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.3164InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.3369InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.3552InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.6694InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.959InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-2 secretion0.0000000005478Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.0003791Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte physiology0.05278Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hippocampus layer morphology0.1026Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.2533Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00004831Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001004Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.001004Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.06754Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.2429Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.00000002398Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.04852Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.06775Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.1178Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.5998Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000000009981InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.000000000135InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0000004017InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00004732InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.009637InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.01908InformativeInherited
Worm Phenotype (WP)protein expression reduced0.0000000003913Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.000765Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.04441Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.137Moderately InformativeInherited
Yeast Phenotype (YP)intracellular transport0.0000205InformativeDirect
Yeast Phenotype (YP)subcellular morphology0.2869InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.1142Least InformativeInherited
Fly Anatomy (FA)adult0.2971Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2974Least InformativeInherited
Fly Anatomy (FA)larva0.8296Least InformativeInherited
Fly Anatomy (FA)neuron0.3682Moderately InformativeInherited
Fly Anatomy (FA)cell component0.002094InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)shoot internode0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect
Plant ANatomical entity (PAN)plant embryo0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)portion of meristem tissue0Least InformativeDirect
Plant ANatomical entity (PAN)vascular leaf0Least InformativeDirect
Plant ANatomical entity (PAN)megasporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)microsporophyll0Least InformativeDirect
Plant ANatomical entity (PAN)sepal0Least InformativeDirect
Plant ANatomical entity (PAN)petal0Least InformativeDirect
Plant ANatomical entity (PAN)stem0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)androecium0Least InformativeDirect
Plant ANatomical entity (PAN)gynoecium0Least InformativeDirect
Plant ANatomical entity (PAN)leaf lamina0Least InformativeDirect
Plant ANatomical entity (PAN)collective leaf structure0Least InformativeDirect
Plant ANatomical entity (PAN)stalk0Least InformativeDirect
Plant ANatomical entity (PAN)branch0Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0Least InformativeDirect
Plant ANatomical entity (PAN)phyllome apex0Least InformativeDirect
Plant ANatomical entity (PAN)microgametophyte0Least InformativeDirect
Plant structure DEvelopment stage (PDE)4 leaf senescence stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.12 twelve leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.02 two leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.10 ten leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.04 four leaves visible stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.4343Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.9814Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.00000000332InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00009366InformativeDirect
Enzyme Commission (EC)Glycosyltransferases1InformativeInherited
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0000000001389Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 171 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SH3-domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]