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Translation proteins SH3-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SH3-like barrel [ 50036] (21)
Superfamily:   Translation proteins SH3-like domain [ 50104] (7)
Families:   Ribosomal proteins L24p and L21e [ 50105] (2)
  eIF5a N-terminal domain-like [ 50110] (3)
  C-terminal domain of ribosomal protein L2 [ 50114]
  N-utilization substance G protein NusG, C-terminal domain [ 82072]
  SPT5 KOW domain-like [ 141242]
  Ribosomal protein L19 [ 141245]
  Ribosomal protein L14e [ 159031]


Superfamily statistics
Genomes (3,262) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 24,080 149,447 46
Proteins 23,915 149,034 46


Functional annotation
General category Information
Detailed category Translation

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.000006881Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.000008057Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000008089Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0002015Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0003205Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.001202Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.006485Least InformativeInherited
Worm Phenotype (WP)larval growth variant0.4393Least InformativeInherited
Worm Phenotype (WP)larval development variant0.4519Least InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.0000001454Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.000002968Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0.00001037Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.00001433Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.0003205Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.00111Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.02834Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.1118Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.5607Moderately InformativeInherited
Worm Phenotype (WP)pleiotropic defects severe early emb0.0000000000001273InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.000000002596InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000006825InformativeDirect
Worm Phenotype (WP)diplotene progression during oogenesis variant0.000000007956InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00000007889InformativeDirect
Worm Phenotype (WP)rachis morphology variant0.00000008407InformativeDirect
Worm Phenotype (WP)early larval arrest0.00054InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.04063InformativeInherited
Worm Phenotype (WP)gonad vesiculated0.0000000008007Highly InformativeDirect
Worm Phenotype (WP)pachytene region organization variant0.000000003091Highly InformativeDirect
Worm Phenotype (WP)oocyte number decreased0.00000000871Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004234Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)heat sensitivity0.0008192InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0Least InformativeDirect
Zebrafish Anatomy (ZA)post-vent region0InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.3111Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)germ cell0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.0008267Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0.04129Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.0524Moderately InformativeInherited
Xenopus ANatomical entity (XAN)immune system0.000008686InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.00001807InformativeDirect
Xenopus ANatomical entity (XAN)limb0.00006296InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.00009834InformativeDirect
Xenopus ANatomical entity (XAN)muscle0.0001225InformativeDirect
Xenopus ANatomical entity (XAN)skeletal system0.001063InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.03217InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.000003365Highly InformativeDirect
Xenopus ANatomical entity (XAN)bone tissue0.0002193Highly InformativeDirect
Xenopus DEvelopment stage (XDE)post-embryonic stage0.243Least InformativeInherited
Xenopus DEvelopment stage (XDE)climax stage0.1266Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 660.0009398InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

InterPro annotation
Cross references IPR008991 SSF50104 Protein matches
Abstract

The fundamental activity of the ribosome is two-fold: to decode the message of the mRNA in the small subunit, and to form a peptide bond between peptidyl-tRNA and aminoacyl-tRNA by a peptidyl transferase activity in the large subunit. Several prokaryotic and eukaryotic proteins that are involved in the translation process contain an SH3-like domain. The structure of the translation protein SH3-like domain is a partly opened beta barrel, where the last strand is interrupted by a 3-10 helical turn. The structure of the RNA-binding C-terminal domain of the Bacillus stearothermophilus ribosomal protein L2 has been shown to adopt the SH3-like barrel topology [PubMed10075918]. The L2 protein is located near the peptidyl transferase centre in the large ribosomal subunit where it may contribute to peptidyl transferase activity, and is involved in the assembly of the 23SrRNA. Likewise, the N-terminal domain of the ubiquitous eukaryotic initiation translation factor 5a (IF-5A) protein adopts the SH3-like barrel topology [PubMed9724718, PubMed9753699]. IF-5A is involved in the initial step of peptide bond formation in translation and in cell-cycle regulation. IF-5A acts as a cofactor of the Rev protein in HIV-1-infected cells and of the Rex protein in T-cell leukaemia virus 1-infected cells.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Translation proteins SH3-like domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the Translation proteins SH3-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]