SUPERFAMILY 1.75 HMM library and genome assignments server

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PDZ domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PDZ domain-like [ 50155]
Superfamily:   PDZ domain-like [ 50156] (6)
Family:   PDZ domain [ 50157] (46)


Family statistics
Genomes (144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,386 24,255 98
Proteins 5,100 16,127 95


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.00000269Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.02756Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000002457Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.00000000242Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000007814Moderately InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase1.746e-16InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000000000009221InformativeDirect
Enzyme Commission (EC)Nitric-oxide synthase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.3227Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.08148InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.4489Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5236Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8345Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.1955Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3312Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of forebrain morphology0.423Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.4523Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.5793Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.05427InformativeInherited
Phenotypic Abnormality (PA)Visual impairment0.1345InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palpebral fissures0.3001InformativeInherited
Phenotypic Abnormality (PA)Abnormal size of the palpebral fissures0.02898Highly InformativeInherited
Phenotypic Abnormality (PA)Atrophy/Degeneration affecting the cerebrum0.04847Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality iris morphology0.05216Highly InformativeInherited
Phenotypic Abnormality (PA)Visual field defect0.06493Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the tongue0.138Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.00002331Least InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic transmission0.00003386Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.243Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.4265Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.4277Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.5954Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.7958Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.001075InformativeInherited
Mammalian Phenotype (MP)abnormal behavioral response to xenobiotic0.01549InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.2787InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.5723InformativeInherited
Mammalian Phenotype (MP)craniorachischisis0.0000227Highly InformativeDirect
Mammalian Phenotype (MP)abnormal miniature endplate potential0.0002715Highly InformativeDirect
Mammalian Phenotype (MP)enhanced paired-pulse facilitation0.0006362Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0004283Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.0005386Least InformativeDirect
Worm Phenotype (WP)cell development variant0.001136Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.02804Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.02804Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.0525Least InformativeInherited
Worm Phenotype (WP)protein expression variant0.0001548Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.001198Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.05652Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.1551Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.4339Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.5478Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.8589Moderately InformativeInherited
Worm Phenotype (WP)spindle variant0.0002958InformativeDirect
Worm Phenotype (WP)brood size variant0.0005312InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.0005809InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.002883InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.005125InformativeInherited
Worm Phenotype (WP)vulva development variant0.02514InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.03687InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.03993InformativeInherited
Worm Phenotype (WP)cell number increased0.0547InformativeInherited
Worm Phenotype (WP)egg laying variant0.06494InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.3029InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.6327InformativeInherited
Worm Phenotype (WP)cell polarity variant0.00000006341Highly InformativeDirect
Worm Phenotype (WP)body muscle dystrophy0.000006009Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0001019Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.0002709Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.001321Highly InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.002536Highly InformativeInherited
Worm Phenotype (WP)cell number decreased0.005229Highly InformativeInherited
Worm Phenotype (WP)epithelial development variant0.00693Highly InformativeInherited
Worm Phenotype (WP)egg laying response to drug variant0.01634Highly InformativeInherited
Worm Phenotype (WP)serotonin response variant0.02715Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.00009513InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.2145Least InformativeInherited
Fly Anatomy (FA)epithelium0.02914Moderately InformativeInherited
Fly Anatomy (FA)female organism0.0706Moderately InformativeInherited
Fly Anatomy (FA)gonad0.07797Moderately InformativeInherited
Fly Anatomy (FA)epithelial cell0.00008126InformativeDirect
Fly Anatomy (FA)somatic cell of ovary0.0003567InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.1789Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3488Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.4874Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6033Moderately InformativeInherited
Zebrafish Anatomy (ZA)spinal cord0.002377Highly InformativeInherited
Zebrafish Anatomy (ZA)ventricular system0.03797Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.08193Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.08685Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.08812Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.00003952Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.0001187Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000003276InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000003872InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000654InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000006191InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000000000000001824Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.00000000000111Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 176 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PDZ domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]