SUPERFAMILY 1.75 HMM library and genome assignments server

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Tissue inhibitor of metalloproteinases, TIMP family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   OB-fold [ 50198] (16)
Superfamily:   TIMP-like [ 50242] (3)
Family:   Tissue inhibitor of metalloproteinases, TIMP [ 50243] (2)


Family statistics
Genomes (66) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 268 689 6
Proteins 267 685 6


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0Moderately InformativeDirect
Disease Ontology (DO)artery disease0.002192Moderately InformativeInherited
Disease Ontology (DO)arthritis0.0006604InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.05777Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.0612Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1719Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.0004089Moderately InformativeDirect
Mammalian Phenotype (MP)increased hematopoietic cell number0.00349Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.008393Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.01075Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.00007241InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte morphology0.0002671InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number0.00004704Highly InformativeDirect
Mammalian Phenotype (MP)increased granulocyte number0.00005153Highly InformativeDirect

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TIMP-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Mouse Phenotype (MP) · Internal database links ]