SUPERFAMILY 1.75 HMM library and genome assignments server

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Interleukin-1 (IL-1) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Family:   Interleukin-1 (IL-1) [ 50362] (5)

Family statistics
Genomes (44) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 227 592 17
Proteins 227 592 17

Disease Ontology (DO)

show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.3436Least InformativeInherited
Disease Ontology (DO)organ system cancer0.3783Least InformativeInherited
Disease Ontology (DO)integumentary system disease0.000003431Moderately InformativeDirect
Disease Ontology (DO)hypersensitivity reaction type II disease0.0003004Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.001827Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.002453Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.006206Moderately InformativeInherited
Disease Ontology (DO)artery disease0.008548Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01925Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.02335Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.02566Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.02601Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0292Moderately InformativeInherited
Disease Ontology (DO)syndrome0.06032Moderately InformativeInherited
Disease Ontology (DO)periodontal disease0.000003543InformativeDirect
Disease Ontology (DO)glomerulonephritis0.000004624InformativeDirect
Disease Ontology (DO)interstitial lung disease0.00001233InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0001354InformativeDirect
Disease Ontology (DO)atherosclerosis0.0001749InformativeDirect
Disease Ontology (DO)overnutrition0.0001749InformativeDirect
Disease Ontology (DO)arthritis0.0001792InformativeDirect
Disease Ontology (DO)coronary artery disease0.0001874InformativeDirect
Disease Ontology (DO)female reproductive system disease0.0001925InformativeDirect
Disease Ontology (DO)scleroderma0.0002352InformativeDirect
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.000394InformativeDirect
Disease Ontology (DO)heart disease0.0007959InformativeDirect
Disease Ontology (DO)parasitic infectious disease0.001308InformativeInherited
Disease Ontology (DO)vasculitis0.001389InformativeInherited
Disease Ontology (DO)liver disease0.001873InformativeInherited
Disease Ontology (DO)myeloid neoplasm0.00288InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.003724InformativeInherited
Disease Ontology (DO)arthropathy0.008016InformativeInherited
Disease Ontology (DO)eye disease0.00805InformativeInherited
Disease Ontology (DO)primary open angle glaucoma0.000002785Highly InformativeDirect
Disease Ontology (DO)polycystic ovary syndrome0.000006566Highly InformativeDirect
Disease Ontology (DO)gastritis0.00001042Highly InformativeDirect
Disease Ontology (DO)spondylitis0.00001112Highly InformativeDirect
Disease Ontology (DO)purpura0.0000179Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.00002219Highly InformativeDirect
Disease Ontology (DO)obstructive lung disease0.00002607Highly InformativeDirect
Disease Ontology (DO)rheumatoid arthritis0.00005233Highly InformativeDirect
Disease Ontology (DO)endometriosis0.00006832Highly InformativeDirect
Disease Ontology (DO)peptic ulcer disease0.0004018Highly InformativeDirect
Disease Ontology (DO)hepatitis0.0004701Highly InformativeDirect
Disease Ontology (DO)multiple myeloma0.000731Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.6476Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.0003989Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.001034Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.07857Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.2975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.3273Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.4112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.0000008244InformativeDirect
Mammalian Phenotype (MP)abnormal skin physiology0.000002992InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.0001088InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.0001844InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.0002245InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte morphology0.0009754InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.000001675Highly InformativeDirect
Mammalian Phenotype (MP)abnormal body temperature homeostasis0.000002078Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to infection0.00002741Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number0.0001844Highly InformativeDirect
Mammalian Phenotype (MP)increased granulocyte number0.0002017Highly InformativeDirect

Document: MP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 33 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Internal database links ]