SUPERFAMILY 1.73 HMM library and genome assignments server


Trypsin-like serine proteases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (165)
Fold:   Trypsin-like serine proteases [ 50493]
  barrel, closed; n=6, S=8; greek-key
duplication: consists of two domains of the same fold
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Families:   Prokaryotic proteases [ 50495] (15)
  Eukaryotic proteases [ 50514] (47)
  Viral proteases [ 50596] (4)
  beta sheet in the first domain is opened rather than forms a barrel
  Viral cysteine protease of trypsin fold [ 50603] (3)


InterPro annotation
Cross references IPR009003 SSF50494 Protein matches
Abstract

This signature recognises a large group of serine and cysteine peptidases (including prokaryotic, eukaryotic and viral), which share a common closed beta barrel structure.


InterPro database

Functional annotation
General category Processes_IC
Detailed category Proteases

Function annotation of SCOP domain superfamilies

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Internal database links

The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments' icon above to view the genome assignments for this superfamily.


Alignments of sequences to

Alignments of sequences to 102 models in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.


It is possible to browse and view the proteins in the genomes which have different combinations of domains including a Trypsin-like serine proteases domain. Click on the 'Domain Combinations' icon.


To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.

There are 102 hidden Markov models representing the Trypsin-like serine proteases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.


Jump to [ Top of page · SCOP classification · InterPro annotation · Functional annotation · Internal database links ]