SUPERFAMILY 1.73 HMM library and genome assignments server


PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (165)
Fold:   PH domain-like barrel [ 50728] (2)
  barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
Superfamily:   PH domain-like [ 50729] (12)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (43)
  Pfam 00169
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Pfam 00640
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  close structural similarity to EVH1 domain
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Pfam 03531; Structure-specific recognition protein family; duplication: comprises tandem repeat of two domains of this fold
  Necap1 N-terminal domain-like [ 141439]
  Pfam 07933; DUF1681
  VPS36 N-terminal domain-like [ 141442]
  PfamB 030385


Superfamily statistics
Genomes (265) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 40,234 13,067 131
Proteins 35,936 11,940 130


Functional annotation
General category Regulation
Detailed category Signal transduction

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 88 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 88 hidden Markov models representing the PH domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]