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Pleckstrin-homology domain (PH domain) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Family:   Pleckstrin-homology domain (PH domain) [ 50730] (47)


Family statistics
Genomes (147) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 7,356 22,474 73
Proteins 7,148 21,855 73


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000001836Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.4013Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3308Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000001585InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000000000001037Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.00000006708Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the ear0.7864Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the inner ear0.251InformativeInherited
Phenotypic Abnormality (PA)Morphological abnormality of the inner ear0.005907Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.06389Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1487Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.3938Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.9151Least InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.02009Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.06557Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.07169Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1255Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1691Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1819Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.2232Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.00002825InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.00008461InformativeDirect
Mammalian Phenotype (MP)abnormal blood coagulation0.05309InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.06568InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.1364InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.5935InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-2 secretion0.00006613Highly InformativeDirect
Mammalian Phenotype (MP)decreased platelet aggregation0.000109Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage B cell morphology0.01018Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.1741Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.000003491Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000003995Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.000003995Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000005413Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00006016Least InformativeDirect
Worm Phenotype (WP)cell development variant0.01462Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0.0000027Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000027Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.000002737Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.000002774Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.000003394Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.00000368Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0002758Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.01146Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.06276Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.06772Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.07823Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.3555Moderately InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0000000002839InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.00000009155InformativeDirect
Worm Phenotype (WP)protein subcellular localization variant0.0000002375InformativeDirect
Worm Phenotype (WP)body bend variant0.0000004169InformativeDirect
Worm Phenotype (WP)tail morphology variant0.000001141InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000008389InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00001294InformativeDirect
Worm Phenotype (WP)fat content variant0.0009405InformativeDirect
Worm Phenotype (WP)body posture variant0.002162InformativeInherited
Worm Phenotype (WP)egg laying variant0.002552InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.003583InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.008495InformativeInherited
Worm Phenotype (WP)endocytic transport defect0.01095InformativeInherited
Worm Phenotype (WP)cell component localization variant0.01255InformativeInherited
Worm Phenotype (WP)defecation variant0.01345InformativeInherited
Worm Phenotype (WP)cell stress response variant0.01703InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.03513InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.04256InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.1116InformativeInherited
Worm Phenotype (WP)drug resistant0.148InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.5619InformativeInherited
Worm Phenotype (WP)growth rate variant0.0000001092Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.00001538Highly InformativeDirect
Worm Phenotype (WP)coelomocyte uptake defective0.00001833Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00002981Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.00003961Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00004992Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.000141Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.0001721Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.0002045Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.0003368Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0004259Highly InformativeDirect
Worm Phenotype (WP)germ cell physiology variant0.01012Highly InformativeInherited
Worm Phenotype (WP)egg laying response to drug variant0.04135Highly InformativeInherited
Worm Phenotype (WP)serotonin response variant0.07387Highly InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.08513Highly InformativeInherited
Worm Phenotype (WP)protein phosphorylation variant0.2207Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.5866Least InformativeInherited
Fly Phenotype (FP)some die during embryonic stage0.0009451Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.007579Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.2939InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases3.695e-16Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.00003285Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.00000000001539Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.04592Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.2363InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000000000001101Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 129 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]