SUPERFAMILY 1.75 HMM library and genome assignments server

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Enabled/VASP homology 1 domain (EVH1 domain) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Family:   Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)

Family statistics
Genomes (131) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,163 3,167 11
Proteins 1,163 3,163 11

Human Phenotype (HP)

show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the ear0Moderately InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.02989Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.0911Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.2873Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6476Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.7875Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.06692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.2043Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2465Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain white matter morphology0.00004641InformativeDirect
Mammalian Phenotype (MP)abnormal neurite morphology0.0007652InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell morphology0.0009201InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.003718InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.007236InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.03576InformativeInherited
Mammalian Phenotype (MP)abnormal fluid regulation0.03699InformativeInherited
Mammalian Phenotype (MP)abnormal sensory capabilities/reflexes/nociception0.07692InformativeInherited
Mammalian Phenotype (MP)enlarged brain ventricles0.000005646Highly InformativeDirect
Mammalian Phenotype (MP)hydrops fetalis0.00004246Highly InformativeDirect
Mammalian Phenotype (MP)abnormal megakaryocyte morphology0.00009797Highly InformativeDirect
Mammalian Phenotype (MP)ectopic neuron0.0001508Highly InformativeDirect
Mammalian Phenotype (MP)abnormal radial glial cell morphology0.0002379Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.00912Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.1231Least InformativeInherited
Xenopus ANatomical entity (XAN)cell part0.00009303Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0009769Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 129 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]