SUPERFAMILY 1.75 HMM library and genome assignments server

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Hemopexin-like domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   4-bladed beta-propeller [ 50922]
Superfamily:   Hemopexin-like domain [ 50923]
Family:   Hemopexin-like domain [ 50924] (5)

Family statistics
Genomes (131) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,546 3,664 11
Proteins 1,484 3,510 10

Enzyme Commission (EC)

show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B0.000005852Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.000005852Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02074Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4217Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.0006939Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.00128Moderately InformativeInherited
Disease Ontology (DO)artery disease0.001395Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.001417Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.003036Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01337Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01719Moderately InformativeInherited
Disease Ontology (DO)disease of metabolism0.1494Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system cancer0.1609Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.1667Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.2193Moderately InformativeInherited
Disease Ontology (DO)Kawasaki disease0.0000003525InformativeDirect
Disease Ontology (DO)female reproductive system disease0.000008105InformativeDirect
Disease Ontology (DO)atherosclerosis0.00006609InformativeDirect
Disease Ontology (DO)scleroderma0.0001053InformativeDirect
Disease Ontology (DO)meningioma0.0005504InformativeDirect
Disease Ontology (DO)arthritis0.0005708InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.0006438InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.0007858InformativeDirect
Disease Ontology (DO)heart disease0.0346InformativeInherited
Disease Ontology (DO)malignant glioma0.04333InformativeInherited
Disease Ontology (DO)male reproductive organ cancer0.05004InformativeInherited
Disease Ontology (DO)eye disease0.05034InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9101InformativeInherited
Disease Ontology (DO)chondrosarcoma0.0000005567Highly InformativeDirect
Disease Ontology (DO)myopia0.000002084Highly InformativeDirect
Disease Ontology (DO)adult astrocytic tumour0.000004942Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.000005137Highly InformativeDirect
Disease Ontology (DO)bronchiectasis0.00008823Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0001065Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0002515Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.0771Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.8327Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.06481Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.2922Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.002023InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.1757InformativeInherited
Phenotypic Abnormality (PA)Metaphyseal widening0.00011Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the femoral neck0.0008151Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.02564Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1225Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.0005061Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.0264Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.04209Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.04812Moderately InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.07029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.1664Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.215Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.5757Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.00002726InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0005017InformativeDirect
Mammalian Phenotype (MP)abnormal response to injury0.0008199InformativeDirect
Mammalian Phenotype (MP)abnormal long bone morphology0.001991InformativeInherited
Mammalian Phenotype (MP)abnormal jaw morphology0.003933InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.01415InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.02039InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.05138InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.1847InformativeInherited
Mammalian Phenotype (MP)aortic aneurysm0.0000197Highly InformativeDirect
Mammalian Phenotype (MP)decreased angiogenesis0.0001211Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0004332Highly InformativeDirect
Mammalian Phenotype (MP)abnormal femur morphology0.0007763Highly InformativeDirect
Mammalian Phenotype (MP)abnormal tumor morphology0.001423Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.01127Highly InformativeInherited
Mammalian Phenotype (MP)abnormal maxilla morphology0.1576Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.000001905Moderately InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)skeletal system0.0002704InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3122Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8655Least InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0001169InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.06948InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Hemopexin-like domain domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]