SUPERFAMILY 1.75 HMM library and genome assignments server

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WD40-repeat family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   7-bladed beta-propeller [ 50964] (14)
Superfamily:   WD40 repeat-like [ 50978] (2)
Family:   WD40-repeat [ 50979] (10)

Family statistics
Genomes (647) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 14,751 47,209 17
Proteins 13,922 43,768 15

Enzyme Commission (EC)

show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.000172Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000009517Moderately InformativeDirect
Enzyme Commission (EC)Cis-trans Isomerases1InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.2468Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2216Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.6796InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.0000004167Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000004442Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.000004442Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00003772Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.00118Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.0492Least InformativeInherited
Worm Phenotype (WP)germ cell development variant0.000004205Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.00001238Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.0003504Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0.00288Moderately InformativeInherited
Worm Phenotype (WP)protein protein interaction variant0.02832Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.05997Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.1155Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.1284Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.3401Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.8236Moderately InformativeInherited
Worm Phenotype (WP)vulva morphology variant0.000005611InformativeDirect
Worm Phenotype (WP)brood size variant0.00002709InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.0006382InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0006519InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.007703InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.08144InformativeInherited
Worm Phenotype (WP)drug resistant0.08849InformativeInherited
Worm Phenotype (WP)alimentary system development variant0.1868InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.314InformativeInherited
Worm Phenotype (WP)vulva development variant0.4047InformativeInherited
Worm Phenotype (WP)dauer arrest variant0.416InformativeInherited
Worm Phenotype (WP)cell number increased0.9109InformativeInherited
Worm Phenotype (WP)nervous system morphology variant1InformativeInherited
Worm Phenotype (WP)cell proliferation increased0.000009846Highly InformativeDirect
Worm Phenotype (WP)multivulva0.00026Highly InformativeDirect
Worm Phenotype (WP)slow development0.0008387Highly InformativeDirect
Worm Phenotype (WP)intestinal development variant0.000903Highly InformativeDirect
Worm Phenotype (WP)general pace of development defective early emb0.001238Highly InformativeInherited
Worm Phenotype (WP)negative chemotaxis variant0.005517Highly InformativeInherited
Worm Phenotype (WP)dauer formation variant0.02886Highly InformativeInherited

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.009712Least InformativeInherited
Zebrafish Anatomy (ZA)cell0.08639Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.2019Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.203Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.2072Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.2253Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.001671Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.02722Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.2211Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.5499Moderately InformativeInherited
Zebrafish Anatomy (ZA)retina0.1249InformativeInherited
Zebrafish Anatomy (ZA)neuron0.2946InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.002971Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal outer nuclear layer0.004215Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal photoreceptor layer0.006568Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0.0000002546Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0.001116Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.02947Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.1978Least InformativeInherited
Xenopus ANatomical entity (XAN)testis0.0000000000112Moderately InformativeDirect
Xenopus ANatomical entity (XAN)germ cell0.00001432Moderately InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0.006979Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.2764Moderately InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant sperm cell0.00005118InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.0000002129Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.938Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.0000000000006535Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.02442Moderately InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.03648Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000001337InformativeDirect
Enzyme Commission (EC)Exoribonucleases producing 5'-phosphomonoesters0.000002965Highly InformativeDirect
Enzyme Commission (EC)Cis-trans isomerases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 35 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a WD40 repeat-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]