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Carbonic anhydrase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Carbonic anhydrase [ 51068]
Superfamily:   Carbonic anhydrase [ 51069]
Families:   Carbonic anhydrase [ 51070]


Superfamily statistics
Genomes (756) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,108 11,050 72
Proteins 3,996 10,838 72


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.000098580.01165Least InformativeInherited
Biological Process (BP)response to stimulus0.000039630.2912Least InformativeInherited
Biological Process (BP)single-organism cellular process11Least InformativeInherited
Biological Process (BP)regulation of biological quality0.00000006730.00000000969Moderately InformativeDirect
Biological Process (BP)response to endogenous stimulus0.0032140.03852Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0025770.004198Moderately InformativeInherited
Biological Process (BP)regulation of localization0.00018340.00277Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.036110.04621Moderately InformativeInherited
Biological Process (BP)single organism signaling0.0021690.3118Moderately InformativeInherited
Biological Process (BP)response to organic substance0.03490.1425Moderately InformativeInherited
Biological Process (BP)organic substance transport0.000000020730.00263Moderately InformativeInherited
Biological Process (BP)ion transport0.0010040.0000007129Moderately InformativeInherited
Biological Process (BP)single-organism transport0.98671Moderately InformativeInherited
Biological Process (BP)cell communication0.00073590.4346Moderately InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.00057870.0004533InformativeDirect
Biological Process (BP)regulation of transmembrane transport0.00047840.0002691InformativeDirect
Biological Process (BP)regulation of ion transport0.0005910.000583InformativeDirect
Biological Process (BP)inorganic ion homeostasis00InformativeDirect
Biological Process (BP)positive regulation of transport0.00025490.002754InformativeInherited
Biological Process (BP)regulation of peptide transport0.07840.0606InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.02890.09746InformativeInherited
Biological Process (BP)cation homeostasis00.2032InformativeInherited
Biological Process (BP)cellular chemical homeostasis0.5781InformativeInherited
Biological Process (BP)response to nitrogen compound0.02180.1419InformativeInherited
Biological Process (BP)behavior0.002080.0001748InformativeInherited
Biological Process (BP)anion transport0.073370.08797InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.00010280.000329Highly InformativeDirect
Biological Process (BP)gas transport0.00000000021290Highly InformativeDirect
Biological Process (BP)one-carbon compound transport0.000000073450.0000000000003733Highly InformativeDirect
Biological Process (BP)positive regulation of transmembrane transport0.000000000045450.00000001078Highly InformativeDirect
Biological Process (BP)regulation of intracellular pH0.00000000000032710.000000000007055Highly InformativeDirect
Biological Process (BP)cellular response to organonitrogen compound0.000010830.00008528Highly InformativeDirect
Biological Process (BP)regulation of ion homeostasis0.000000000000019240.000000000004728Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.0010970.001823Highly InformativeInherited
Biological Process (BP)locomotory behavior0.000036020.03583Highly InformativeInherited
Molecular Function (MF)lyase activity00Moderately InformativeDirect
Molecular Function (MF)hydro-lyase activity00InformativeDirect
Molecular Function (MF)carbonate dehydratase activity00Highly InformativeDirect
Cellular Component (CC)apical part of cell0.00000017780.000006008InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.01165 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2912 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.9528 Least Informative Inherited
Biological Process (BP) ion transport 0.0000007129 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.00000000969 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.03852 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.004198 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.00277 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.04621 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.3118 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.1425 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.00263 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.289 Moderately Informative Inherited
Biological Process (BP) cell communication 0.4346 Moderately Informative Inherited
Biological Process (BP) central nervous system development 0.0001584 Informative Direct
Biological Process (BP) behavior 0.0001748 Informative Direct
Biological Process (BP) metal ion transport 0.0000002365 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0004533 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.0002691 Informative Direct
Biological Process (BP) regulation of ion transport 0.000583 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.002754 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.0606 Informative Inherited
Biological Process (BP) transmembrane transport 0.01264 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.09746 Informative Inherited
Biological Process (BP) cation homeostasis 0.2032 Informative Inherited
Biological Process (BP) cellular chemical homeostasis 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 0.1419 Informative Inherited
Biological Process (BP) anion transport 0.08797 Informative Inherited
Biological Process (BP) sodium ion transport 0 Highly Informative Direct
Biological Process (BP) G-protein coupled receptor signaling pathway 0.000329 Highly Informative Direct
Biological Process (BP) gas transport 0 Highly Informative Direct
Biological Process (BP) one-carbon compound transport 0.0000000000003733 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00000001078 Highly Informative Direct
Biological Process (BP) regulation of intracellular pH 0.000000000007055 Highly Informative Direct
Biological Process (BP) cellular response to organonitrogen compound 0.00008528 Highly Informative Direct
Biological Process (BP) inorganic cation transmembrane transport 0.0000000003044 Highly Informative Direct
Biological Process (BP) regulation of ion homeostasis 0.000000000004728 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.001823 Highly Informative Inherited
Biological Process (BP) locomotory behavior 0.03583 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.00003044 Moderately Informative Direct
Molecular Function (MF) lyase activity 0 Moderately Informative Direct
Molecular Function (MF) phosphatase activity 0.0000002456 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) carbonate dehydratase activity 0 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.00208 Highly Informative Inherited
Cellular Component (CC) membrane 0.00004399 Least Informative Direct
Cellular Component (CC) plasma membrane 0.00000001398 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0009729 Moderately Informative Direct
Cellular Component (CC) cell surface 0.0000814 Informative Direct
Cellular Component (CC) apical part of cell 0.000006008 Informative Direct
Cellular Component (CC) side of membrane 0.0002856 Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00001063 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Lyases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.4594Least InformativeInherited
Enzyme Commission (EC)Hydro-lyases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.004856Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000002434InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.00001448Moderately InformativeDirect
Biological processVirus entry into host cell0.00000008492InformativeDirect
Cellular componentMembrane0.1807Least InformativeInherited
Cellular componentSecreted0.000000000008018Moderately InformativeDirect
Cellular componentVirion0.0001938Moderately InformativeDirect
Cellular componentGPI-anchor0.000004122InformativeDirect
Cellular componentExtracellular matrix0.00001299InformativeDirect
Cellular componentPeriplasm0.00007974InformativeDirect
Cellular componentViral envelope protein0.0000000008984Highly InformativeDirect
Developmental stageLate protein0.000000006407Least InformativeDirect
DiseaseDisease mutation0.0002449Least InformativeDirect
DomainSignal6.227e-16Least InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationLyase0Moderately InformativeDirect
Post-translational modificationProtein phosphatase0.00000009266InformativeDirect
Post-translational modificationGlycoprotein0.00000006627Least InformativeDirect
Post-translational modificationDisulfide bond0.0000008089Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001148 SSF51069 Protein matches
Abstract

Synonym(s): Carbonic dehydratase, Carbonic anhydrase

Carbonate dehydratase (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. Eight enzymatic and evolutionary related forms of carbonic anhydrase are currently known to exist in vertebrates: three cytosolic isozymes (CA-I, CA-II and CA-III); two membrane-bound forms (CA-IV and CA-VII); a mitochondrial form (CA-V); a secreted salivary form (CA-VI); and a yet uncharacterised isozyme.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 10 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Carbonic anhydrase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 10 hidden Markov models representing the Carbonic anhydrase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]