SUPERFAMILY 1.75 HMM library and genome assignments server

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beta-Roll superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Single-stranded right-handed beta-helix [ 51125] (8)
Superfamily:   beta-Roll [ 51120]
Families:   Serralysin-like metalloprotease, C-terminal domain [ 51121]


Superfamily statistics
Genomes (710) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,048 84,294 13
Proteins 3,086 32,866 13


Functional annotation
General category Processes_IC
Detailed category Proteases

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0.000000001008Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.000004884Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0.000000001853Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.00009486Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.0000000001399InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.00000000000001339Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011049 SSF51120 Protein matches
Abstract

Serralysin is a bacterial Zn-endopeptidase that acts as a virulence factor to cause tissue damage and anaphylactic response [PubMed12072965]. Many Zn-endopeptidases contain the metal binding motif HexxHxxGxxH; in addition to these coordinated histidine residues, serralysin contains a coordinated tyrosine residue that is unique to the astacin-like Zn enzymes. The Zn-endopeptidases containing the histidine motif are structurally similar to one another, containing an N-terminal catalytic domain that belongs to the zincin family, and a C-terminal beta-helix metal-binding domain. These peptidase include the astacin family, snake venom Zn-endopeptidases, the extracellular metalloproteases from Serratia sp., Pseudomonas sp. and Erwinia sp., and the matrixins.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a beta-Roll domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the beta-Roll superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Enzyme Commission (EC) · Internal database links ]