SUPERFAMILY 1.75 HMM library and genome assignments server

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cAMP-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Double-stranded beta-helix [ 51181] (7)
Superfamily:   cAMP-binding domain-like [ 51206] (3)
Family:   cAMP-binding domain [ 51210] (12)


Family statistics
Genomes (852) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,596 11,435 30
Proteins 2,960 9,739 26


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000001257Moderately InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.1402Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.5585Least InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.02979Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2424Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal electroretinogram0.00003688Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.0006789Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.03748Least InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.0596Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.3504Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.355Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.4278Moderately InformativeInherited
Mammalian Phenotype (MP)decreased neuron number0.04072InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.5304InformativeInherited
Mammalian Phenotype (MP)decreased retinal photoreceptor cell number0.0009045Highly InformativeDirect
Mammalian Phenotype (MP)abnormal olfactory bulb morphology0.001568Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.01662Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.03476Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.03476Least InformativeInherited
Worm Phenotype (WP)cell development variant0.0403Least InformativeInherited
Worm Phenotype (WP)movement variant0.0000386Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.0001533Moderately InformativeDirect
Worm Phenotype (WP)locomotion variant0.001529Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.005849Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.02522Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.02522Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.02532Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.02542Moderately InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.0001156InformativeDirect
Worm Phenotype (WP)drug resistant0.0004365InformativeDirect
Worm Phenotype (WP)head movement variant0.0006239InformativeDirect
Worm Phenotype (WP)directionality variant0.0009463InformativeDirect
Worm Phenotype (WP)body bend variant0.001375InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.002846InformativeInherited
Worm Phenotype (WP)body posture variant0.006326InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.02215InformativeInherited
Worm Phenotype (WP)egg laying variant0.08313InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.1339InformativeInherited
Worm Phenotype (WP)odorant positive chemotaxis variant0.000000006198Highly InformativeDirect
Worm Phenotype (WP)positive chemotaxis defective0.00000003306Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.0000004208Highly InformativeDirect
Worm Phenotype (WP)carbon dioxide avoidance variant0.000000656Highly InformativeDirect
Worm Phenotype (WP)neuronal cell fate specification variant0.000001932Highly InformativeDirect
Worm Phenotype (WP)neuron physiology variant0.00006262Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.0001881Highly InformativeDirect
Worm Phenotype (WP)dumpy0.0001964Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.0002679Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.0002821Highly InformativeDirect
Worm Phenotype (WP)forward point velocity variant0.0002969Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.0003273Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0003353Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.0003395Highly InformativeDirect
Worm Phenotype (WP)egg laying defective0.0004001Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.0006487Highly InformativeDirect
Worm Phenotype (WP)male mating variant0.0006882Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0006882Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.0008241Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis variant0.1284Highly InformativeInherited
Worm Phenotype (WP)negative chemotaxis variant0.2161Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)sensory perception defective0.0003487Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases0.982Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000001543InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a cAMP-binding domain-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]