Duplicated hybrid motif superfamily
SCOP classification
InterPro annotation
| Cross references | IPR011055 SSF51261 Protein matches |
| Abstract | The duplicated hybrid motif is a structural motif that is found in certain glucose-permease-like enzymes, and consists of a half-barrel beta-sheet of eight strands that is sandwiched with two 3-stranded beta-sheets. Enzymes displaying this motif include domain IIa of the glucose-specific permease from bacteria , which is part of the phosphoenolpyruvate:sugar phosphotransfer system (PTS), a bacterial and mycoplasma system responsible for the uptake of some sugars and their concomitant phosphorylation [ 9705652].
This structural motif is also found in peptidoglycan hydrolase LytM, a member of peptidase family M23, although it contains an extra N-terminal, non-conserved beta-sheet subdomain. |
InterPro database
Functional annotation
| General category | Metabolism |
| Detailed category | Carbohydrate metabolism and transport |
Function annotation of SCOP domain superfamilies
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Internal database links
The SUPERFAMILY hidden Markov model library has been used to carry
out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments'
icon above to view the genome assignments for this superfamily.
Alignments of sequences to Alignments of sequences to 4 models
in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical
are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.
It is possible to browse and view the proteins in the genomes which have
different combinations of domains including a Duplicated hybrid motif domain. Click on the 'Domain Combinations' icon.
To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.
Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.
There are 4 hidden Markov models representing the Duplicated hybrid motif superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.
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