SUPERFAMILY 1.73 HMM library and genome assignments server


Metallo-dependent hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
  contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites
Superfamily:   Metallo-dependent hydrolases [ 51556] (15)
Families:   Adenosine/AMP deaminase [ 51557] (2)
  Dihydroorotase [ 63917]
  Cytosine deaminase catalytic domain [ 69390]
  alpha-subunit of urease, catalytic domain [ 51560]
  Hydantoinase (dihydropyrimidinase), catalytic domain [ 75073] (5)
  Hypothetical protein TM0936, probable catalytic domain [ 82258]
  Isoaspartyl dipeptidase, catalytic domain [ 89489]
  N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain [ 82261]
  D-aminoacylase, catalytic domain [ 82264]
  TatD Mg-dependent DNase-like [ 82267] (4)
  Phosphotriesterase-like [ 51564] (2)
  Renal dipeptidase [ 75079]
  Uronate isomerase TM0064 [ 75082]
  contains all-alpha subdomain inserted after the first strand
  Adenine deaminase-like [ 141816]
  PP1699/LP2961-like [ 141819] (5)
  Pfam 04909; Amidohydrolase; stand-alone domain


Functional annotation
General category Metabolism
Detailed category Other enzymes

Function annotation of SCOP domain superfamilies

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Internal database links

The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments' icon above to view the genome assignments for this superfamily.


Alignments of sequences to

Alignments of sequences to 39 models in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.


It is possible to browse and view the proteins in the genomes which have different combinations of domains including a Metallo-dependent hydrolases domain. Click on the 'Domain Combinations' icon.


To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.

There are 39 hidden Markov models representing the Metallo-dependent hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]