SUPERFAMILY 1.73 HMM library and genome assignments server


Metallo-dependent hydrolases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
  contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites
Superfamily:   Metallo-dependent hydrolases [ 51556] (15)
Families:   Adenosine/AMP deaminase [ 51557] (2)
  Dihydroorotase [ 63917]
  Cytosine deaminase catalytic domain [ 69390]
  alpha-subunit of urease, catalytic domain [ 51560]
  Hydantoinase (dihydropyrimidinase), catalytic domain [ 75073] (5)
  Hypothetical protein TM0936, probable catalytic domain [ 82258]
  Isoaspartyl dipeptidase, catalytic domain [ 89489]
  N-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain [ 82261]
  D-aminoacylase, catalytic domain [ 82264]
  TatD Mg-dependent DNase-like [ 82267] (4)
  Phosphotriesterase-like [ 51564] (2)
  Renal dipeptidase [ 75079]
  Uronate isomerase TM0064 [ 75082]
  contains all-alpha subdomain inserted after the first strand
  Adenine deaminase-like [ 141816]
  PP1699/LP2961-like [ 141819] (5)
  Pfam 04909; Amidohydrolase; stand-alone domain


Superfamily statistics
Genomes (1,230) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 16,639 18,129 80
Proteins 16,601 18,098 80


Functional annotation
General category Metabolism
Detailed category Other enzymes

Function annotation of SCOP domain superfamilies

Jump to [ Top of page · SCOP classification · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 39 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Metallo-dependent hydrolases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 39 hidden Markov models representing the Metallo-dependent hydrolases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]