SUPERFAMILY 1.73 HMM library and genome assignments server


Aldolase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
  contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites
Superfamily:   Aldolase [ 51569] (8)
Families:   Class I aldolase [ 51570] (12)
  the catalytic lysine forms schiff-base intermediate with substrate
possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels
  Class II FBP aldolase [ 51591] (2)
  metal-dependent
  5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [ 51594]
  hybrid of classes I and II aldolase
  Class I DAHP synthetase [ 51599] (2)
  HMGL-like [ 89494] (3)
  Pfam 00682
  NeuB-like [ 110368] (2)
  Pfam 03102
  GatZ-like [ 141837]
  Pfam 08013
  Class-II DAHP synthetase [ 141840]
  Pfam 01474


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Function annotation of SCOP domain superfamilies

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Internal database links

The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level. Click on the 'Genome Assignments' icon above to view the genome assignments for this superfamily.


Alignments of sequences to

Alignments of sequences to 56 models in this superfamily are available by clicking on the superfamily level 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequences may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own.


It is possible to browse and view the proteins in the genomes which have different combinations of domains including a Aldolase domain. Click on the 'Domain Combinations' icon.


To view the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom click on the 'TaxViz' icon above. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Undirected domain occurrence networks are available for all superfamilies. Nodes in these networks represent genomes. Connections between nodes represent the presence of domain architectures, which contain the superfamily of interest, in both genomes.

There are 56 hidden Markov models representing the Aldolase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be viewed by clicking on the icon above.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]