SUPERFAMILY 1.73 HMM library and genome assignments server


Cobalamin (vitamin B12)-dependent enzymes superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (141)
  Mainly parallel beta sheets (beta-alpha-beta units)
Fold:   TIM beta/alpha-barrel [ 51350] (33)
  contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites
Superfamily:   Cobalamin (vitamin B12)-dependent enzymes [ 51703] (4)
Families:   Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain [ 51704] (2)
  the subunits are clearly related but only one (alpha) is active
  Glutamate mutase, large subunit [ 51707]
  Diol dehydratase, alpha subunit [ 51710]
  D-lysine 5,6-aminomutase alpha subunit, KamD [ 117392]
  most similar to the glutamate mutase subunit; contains second cofactor, PLP


Superfamily statistics
Genomes (429) UniProt 15.0 PDB chains (SCOP 1.73)
Domains 851 1,053 8
Proteins 848 1,051 8


Functional annotation
General category Metabolism
Detailed category Coenzyme metabolism and transport

Function annotation of SCOP domain superfamilies

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cobalamin (vitamin B12)-dependent enzymes domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the Cobalamin (vitamin B12)-dependent enzymes superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Internal database links ]