SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


NAD(P)-binding Rossmann-fold domains superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Families:   Alcohol dehydrogenase-like, C-terminal domain [ 51736] (16)
  Tyrosine-dependent oxidoreductases [ 51751] (70)
  Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [ 51800] (22)
  Formate/glycerate dehydrogenases, NAD-domain [ 51830] (10)
  Siroheme synthase N-terminal domain-like [ 75110] (2)
  LDH N-terminal domain-like [ 51848] (8)
  6-phosphogluconate dehydrogenase-like, N-terminal domain [ 51868] (18)
  Aminoacid dehydrogenase-like, C-terminal domain [ 51883] (11)
  Potassium channel NAD-binding domain [ 63944] (4)
  Transcriptional repressor Rex, C-terminal domain [ 102174]
  CoA-binding domain [ 51900] (5)
  Ornithine cyclodeaminase-like [ 110436] (2)


Superfamily statistics
Genomes (3,260) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 359,985 2,030,253 522
Proteins 348,950 1,973,150 519


Functional annotation
General category General
Detailed category Small molecule binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process00Least InformativeDirect
Biological Process (BP)biosynthetic process0.00000000002140Least InformativeDirect
Biological Process (BP)response to stimulus11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process11Least InformativeInherited
Biological Process (BP)primary metabolic process0.67671Least InformativeInherited
Biological Process (BP)cellular aromatic compound metabolic process11Least InformativeInherited
Biological Process (BP)heterocycle metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)biological regulation11Least InformativeInherited
Biological Process (BP)cellular nitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)single-organism cellular process0.58930.00002352Least InformativeInherited
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)small molecule biosynthetic process0.000078020.0000000007429Moderately InformativeDirect
Biological Process (BP)carbohydrate metabolic process0.00015890Moderately InformativeDirect
Biological Process (BP)system development11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis11Moderately InformativeInherited
Biological Process (BP)single organism signaling11Moderately InformativeInherited
Biological Process (BP)cell communication11Moderately InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.0000077151Moderately InformativeInherited
Biological Process (BP)protein complex biogenesis0.00000000014320.07119Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.0071281Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.83651Moderately InformativeInherited
Biological Process (BP)cellular macromolecule biosynthetic process0.93771Moderately InformativeInherited
Biological Process (BP)multi-organism process11Moderately InformativeInherited
Biological Process (BP)reproduction11Moderately InformativeInherited
Biological Process (BP)aromatic compound biosynthetic process11Moderately InformativeInherited
Biological Process (BP)heterocycle biosynthetic process11Moderately InformativeInherited
Biological Process (BP)carbohydrate derivative metabolic process10.0000000004991Moderately InformativeInherited
Biological Process (BP)cofactor metabolic process0.0017940Moderately InformativeInherited
Biological Process (BP)organic cyclic compound biosynthetic process0.48740.009427Moderately InformativeInherited
Biological Process (BP)monocarboxylic acid metabolic process00.00321Moderately InformativeInherited
Biological Process (BP)protein oligomerization00.000000000009971InformativeDirect
Biological Process (BP)fatty acid metabolic process00.00000000002548InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process00.0002196InformativeDirect
Biological Process (BP)regulation of hormone levels0.00000000032650.00000001007InformativeDirect
Biological Process (BP)fatty acid derivative metabolic process0.0000016110.000000001999InformativeDirect
Biological Process (BP)pteridine-containing compound metabolic process0.0000055410.000000000000005614InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000023060.0000000002414InformativeDirect
Biological Process (BP)secondary metabolic process0.000025290InformativeDirect
Biological Process (BP)polysaccharide metabolic process0.00022990.00000000000003972InformativeDirect
Biological Process (BP)drug metabolic process0.00067210.0001713InformativeDirect
Biological Process (BP)circulatory system development0.24821InformativeInherited
Biological Process (BP)G-protein coupled receptor signaling pathway0.20051InformativeInherited
Biological Process (BP)cellular ketone metabolic process0.010260.000008382InformativeInherited
Biological Process (BP)tetrapyrrole metabolic process0.031280.0001094InformativeInherited
Biological Process (BP)pigment metabolic process0.19161InformativeInherited
Biological Process (BP)carbohydrate biosynthetic process0.03820.00000000000001267InformativeInherited
Biological Process (BP)multi-organism reproductive process0.58011InformativeInherited
Biological Process (BP)multicellular organism reproduction0.59081InformativeInherited
Biological Process (BP)single organism reproductive process0.85851InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.58030.243InformativeInherited
Biological Process (BP)coenzyme biosynthetic process0.44511InformativeInherited
Biological Process (BP)cellular hormone metabolic process00Highly InformativeDirect
Biological Process (BP)cellular polysaccharide biosynthetic process0.0000000079690Highly InformativeDirect
Biological Process (BP)pteridine-containing compound biosynthetic process0.0000041250.0000006749Highly InformativeDirect
Biological Process (BP)steroid biosynthetic process0.0000058630.000000003419Highly InformativeDirect
Biological Process (BP)hormone biosynthetic process0.000014990.0000428Highly InformativeDirect
Biological Process (BP)nucleotide-sugar metabolic process0.000023490Highly InformativeDirect
Biological Process (BP)diterpenoid metabolic process0.000097020.00000004705Highly InformativeDirect
Biological Process (BP)quinone metabolic process0.0026960.9956Highly InformativeInherited
Biological Process (BP)female gamete generation0.0013611Highly InformativeInherited
Biological Process (BP)multi-multicellular organism process0.00059460.3823Highly InformativeInherited
Molecular Function (MF)binding11Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)oxidoreductase activity00Moderately InformativeDirect
Molecular Function (MF)small molecule binding0.000000017040Moderately InformativeDirect
Molecular Function (MF)anion binding0.33450.0214Moderately InformativeInherited
Molecular Function (MF)lyase activity10.8282Moderately InformativeInherited
Molecular Function (MF)isomerase activity0.86360.001711Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)coenzyme binding00InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.000064570InformativeDirect
Molecular Function (MF)hydro-lyase activity0.94360InformativeInherited
Molecular Function (MF)molecular transducer activity11InformativeInherited
Molecular Function (MF)signal transducer activity11InformativeInherited
Molecular Function (MF)NADP binding00Highly InformativeDirect
Molecular Function (MF)NAD binding0.0000000000000093130Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor0.00012570Highly InformativeDirect
Molecular Function (MF)oxidoreductase activity, acting on the CH-NH group of donors0.63240.03315Highly InformativeInherited
Molecular Function (MF)oxidoreductase activity, acting on the CH-CH group of donors0.0000092970.2155Highly InformativeInherited
Molecular Function (MF)transmembrane signaling receptor activity0.91731Highly InformativeInherited
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.026230.00006318Highly InformativeInherited
Cellular Component (CC)cytoplasmic part11Least InformativeInherited
Cellular Component (CC)intracellular organelle part11Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle11Least InformativeInherited
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)whole membrane11Moderately InformativeInherited
Cellular Component (CC)bounding membrane of organelle11Moderately InformativeInherited
Cellular Component (CC)microbody0.011470InformativeInherited
Cellular Component (CC)microbody membrane0.000031430.000000002984Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) biosynthetic process 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00002352 Least Informative Direct
Biological Process (BP) response to stimulus 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0000000007429 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular amino acid metabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.0000000004991 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0000000006908 Moderately Informative Direct
Biological Process (BP) organophosphate biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular developmental process 1 Moderately Informative Inherited
Biological Process (BP) system development 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.07119 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.1491 Moderately Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0.02201 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 1 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.4893 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 1 Moderately Informative Inherited
Biological Process (BP) cell communication 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.00321 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.009427 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.3568 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.008092 Moderately Informative Inherited
Biological Process (BP) protein oligomerization 0.000000000009971 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.00000000002548 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.0002196 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000001007 Informative Direct
Biological Process (BP) fatty acid derivative metabolic process 0.000000001999 Informative Direct
Biological Process (BP) pteridine-containing compound metabolic process 0.000000000000005614 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0.0000000002414 Informative Direct
Biological Process (BP) secondary metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0.00000000000003972 Informative Direct
Biological Process (BP) drug metabolic process 0.0001713 Informative Direct
Biological Process (BP) alcohol metabolic process 0.0003126 Informative Direct
Biological Process (BP) cellular ketone metabolic process 0.000008382 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0.0001094 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.00000000000001267 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.000001072 Informative Direct
Biological Process (BP) cellular aldehyde metabolic process 0 Informative Direct
Biological Process (BP) organic hydroxy compound biosynthetic process 0.00000005533 Informative Direct
Biological Process (BP) nicotinamide nucleotide metabolic process 0 Informative Direct
Biological Process (BP) glutamine family amino acid metabolic process 0.00002243 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0.000004224 Informative Direct
Biological Process (BP) dicarboxylic acid metabolic process 0.00000000000009633 Informative Direct
Biological Process (BP) ATP metabolic process 0.0000006145 Informative Direct
Biological Process (BP) nucleoside diphosphate metabolic process 0.00006504 Informative Direct
Biological Process (BP) alpha-amino acid biosynthetic process 0.0009061 Informative Direct
Biological Process (BP) movement of cell or subcellular component 1 Informative Inherited
Biological Process (BP) circulatory system development 1 Informative Inherited
Biological Process (BP) cell wall organization or biogenesis 0.2948 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) G-protein coupled receptor signaling pathway 1 Informative Inherited
Biological Process (BP) membrane organization 1 Informative Inherited
Biological Process (BP) cell death 1 Informative Inherited
Biological Process (BP) phosphorylation 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) cell development 1 Informative Inherited
Biological Process (BP) behavior 1 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.243 Informative Inherited
Biological Process (BP) pigment metabolic process 1 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) locomotion 1 Informative Inherited
Biological Process (BP) central nervous system development 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) liposaccharide metabolic process 0.2674 Informative Inherited
Biological Process (BP) aspartate family amino acid metabolic process 0.1792 Informative Inherited
Biological Process (BP) carboxylic acid catabolic process 1 Informative Inherited
Biological Process (BP) cellular respiration 0.4752 Informative Inherited
Biological Process (BP) water-soluble vitamin biosynthetic process 0.7047 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) metal ion transport 0.4314 Informative Inherited
Biological Process (BP) coenzyme biosynthetic process 1 Informative Inherited
Biological Process (BP) sulfur compound biosynthetic process 0.599 Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0 Highly Informative Direct
Biological Process (BP) pteridine-containing compound biosynthetic process 0.0000006749 Highly Informative Direct
Biological Process (BP) steroid biosynthetic process 0.000000003419 Highly Informative Direct
Biological Process (BP) hormone biosynthetic process 0.0000428 Highly Informative Direct
Biological Process (BP) nucleotide-sugar metabolic process 0 Highly Informative Direct
Biological Process (BP) diterpenoid metabolic process 0.00000004705 Highly Informative Direct
Biological Process (BP) NADP metabolic process 0.0000001306 Highly Informative Direct
Biological Process (BP) phenylpropanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) protein homotetramerization 0.0000002552 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.0000000000001138 Highly Informative Direct
Biological Process (BP) lipopolysaccharide metabolic process 0.000003373 Highly Informative Direct
Biological Process (BP) glucose 6-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) glyceraldehyde-3-phosphate metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.00000000001454 Highly Informative Direct
Biological Process (BP) polyketide metabolic process 0.00000000002812 Highly Informative Direct
Biological Process (BP) fermentation 0.0007363 Highly Informative Direct
Biological Process (BP) secondary metabolite biosynthetic process 0.001716 Highly Informative Inherited
Biological Process (BP) phenol-containing compound metabolic process 0.007748 Highly Informative Inherited
Biological Process (BP) alcohol biosynthetic process 0.002814 Highly Informative Inherited
Biological Process (BP) benzene-containing compound metabolic process 0.07623 Highly Informative Inherited
Biological Process (BP) cell wall biogenesis 0.00214 Highly Informative Inherited
Biological Process (BP) apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of protein stability 0.0282 Highly Informative Inherited
Biological Process (BP) response to alcohol 0.2571 Highly Informative Inherited
Biological Process (BP) single-organism behavior 1 Highly Informative Inherited
Biological Process (BP) glucose metabolic process 1 Highly Informative Inherited
Biological Process (BP) cell maturation 0.8884 Highly Informative Inherited
Biological Process (BP) neuron development 1 Highly Informative Inherited
Biological Process (BP) quinone metabolic process 0.9956 Highly Informative Inherited
Biological Process (BP) xenobiotic metabolic process 0.0716 Highly Informative Inherited
Biological Process (BP) polyol metabolic process 1 Highly Informative Inherited
Biological Process (BP) response to carbohydrate 0.2611 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) brain development 1 Highly Informative Inherited
Biological Process (BP) monosaccharide catabolic process 0.007077 Highly Informative Inherited
Biological Process (BP) alcohol catabolic process 0.08511 Highly Informative Inherited
Biological Process (BP) cellular carbohydrate catabolic process 0.02397 Highly Informative Inherited
Biological Process (BP) fatty acid derivative biosynthetic process 0.00135 Highly Informative Inherited
Biological Process (BP) serine family amino acid metabolic process 1 Highly Informative Inherited
Biological Process (BP) vitamin B6 metabolic process 0.002242 Highly Informative Inherited
Biological Process (BP) pyridine-containing compound biosynthetic process 0.4934 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.3823 Highly Informative Inherited
Biological Process (BP) response to osmotic stress 0.3548 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 1 Highly Informative Inherited
Biological Process (BP) Golgi vesicle transport 1 Highly Informative Inherited
Biological Process (BP) NAD metabolic process 1 Highly Informative Inherited
Biological Process (BP) icosanoid metabolic process 1 Highly Informative Inherited
Biological Process (BP) branched-chain amino acid metabolic process 0.05168 Highly Informative Inherited
Biological Process (BP) citrate metabolic process 0.595 Highly Informative Inherited
Biological Process (BP) isoprenoid biosynthetic process 0.03244 Highly Informative Inherited
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.0214 Moderately Informative Inherited
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) lyase activity 0.8282 Moderately Informative Inherited
Molecular Function (MF) isomerase activity 0.001711 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0 Informative Direct
Molecular Function (MF) hydro-lyase activity 0 Informative Direct
Molecular Function (MF) carbon-carbon lyase activity 1 Informative Inherited
Molecular Function (MF) amide binding 1 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 0.4756 Informative Inherited
Molecular Function (MF) active transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 0.1118 Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 1 Informative Inherited
Molecular Function (MF) molecular transducer activity 1 Informative Inherited
Molecular Function (MF) signal transducer activity 1 Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 1 Informative Inherited
Molecular Function (MF) ligase activity 1 Informative Inherited
Molecular Function (MF) NADP binding 0 Highly Informative Direct
Molecular Function (MF) NAD binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.00006318 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000000001146 Highly Informative Direct
Molecular Function (MF) intramolecular oxidoreductase activity, transposing C=C bonds 0.00000005638 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring nitrogenous groups 0.0002872 Highly Informative Direct
Molecular Function (MF) hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.000305 Highly Informative Direct
Molecular Function (MF) carboxy-lyase activity 0.1292 Highly Informative Inherited
Molecular Function (MF) modified amino acid binding 0.1989 Highly Informative Inherited
Molecular Function (MF) vitamin binding 1 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH group of donors 0.03315 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-CH group of donors 0.2155 Highly Informative Inherited
Molecular Function (MF) secondary active transmembrane transporter activity 0.5829 Highly Informative Inherited
Molecular Function (MF) gated channel activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring hexosyl groups 1 Highly Informative Inherited
Molecular Function (MF) monosaccharide binding 1 Highly Informative Inherited
Molecular Function (MF) ion channel activity 1 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.5313 Highly Informative Inherited
Molecular Function (MF) oxidoreductase activity, acting on the CH-NH2 group of donors 0.06861 Highly Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) organelle envelope 0.8139 Moderately Informative Inherited
Cellular Component (CC) mitochondrial part 0.03878 Moderately Informative Inherited
Cellular Component (CC) transferase complex 1 Moderately Informative Inherited
Cellular Component (CC) whole membrane 1 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) bounding membrane of organelle 1 Moderately Informative Inherited
Cellular Component (CC) microbody 0 Informative Direct
Cellular Component (CC) plastid 0.00001426 Informative Direct
Cellular Component (CC) side of membrane 1 Informative Inherited
Cellular Component (CC) supramolecular polymer 1 Informative Inherited
Cellular Component (CC) Golgi apparatus 1 Informative Inherited
Cellular Component (CC) external encapsulating structure 0.004767 Informative Inherited
Cellular Component (CC) microbody membrane 0.000000002984 Highly Informative Direct
Cellular Component (CC) lipid particle 0.0009988 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.00004257 Highly Informative Direct
Cellular Component (CC) contractile fiber part 1 Highly Informative Inherited
Cellular Component (CC) myofibril 1 Highly Informative Inherited
Cellular Component (CC) peroxisomal part 0.1836 Highly Informative Inherited
Cellular Component (CC) Golgi subcompartment 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Ligases1Least InformativeInherited
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.000000000003598Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than meth1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ether bonds0InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.00000000000003141InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000006968InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00002386InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.00002386InformativeDirect
Enzyme Commission (EC)Intramolecular lyases1InformativeInherited
Enzyme Commission (EC)Sole sub-subclass for lyases that do not belong in1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Acting on phosphates1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxyl group as accep1InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)3-hydroxybutyryl-CoA epimerase0Highly InformativeDirect
Enzyme Commission (EC)Sirohydrochlorin ferrochelatase0Highly InformativeDirect
Enzyme Commission (EC)Uroporphyrinogen-III C-methyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Glutamyl-tRNA reductase0Highly InformativeDirect
Enzyme Commission (EC)UDP-4-amino-4-deoxy-L-arabinose formyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Dodecenoyl-CoA isomerase0Highly InformativeDirect
Enzyme Commission (EC)Enoyl-CoA hydratase0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000006012Highly InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0.0000000000104Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.00000000002282Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.0000000001952Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.000000001785Highly InformativeDirect
Enzyme Commission (EC)1-deoxy-D-xylulose-5-phosphate reductoisomerase0.000000004825Highly InformativeDirect
Enzyme Commission (EC)NAD(P)(+) transhydrogenase (AB-specific)0.0000001173Highly InformativeDirect
Enzyme Commission (EC)3-phosphoshikimate 1-carboxyvinyltransferase0.0000001901Highly InformativeDirect
Enzyme Commission (EC)Aspartate kinase0.0000008852Highly InformativeDirect
Enzyme Commission (EC)3-hydroxyacyl-CoA dehydrogenase0.00004289Highly InformativeDirect
Enzyme Commission (EC)Succinate--CoA ligase (ADP-forming)0.0004845Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donor1Highly InformativeInherited

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9873Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1016Moderately InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0.8513Least InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.01884Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.4573InformativeInherited
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.4714Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant1Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant1Least InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.9368Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)metabolism and growth0.7272Least InformativeInherited
Yeast Phenotype (YP)nutrient utilization0.3948Moderately InformativeInherited
Yeast Phenotype (YP)utilization of nitrogen source0.0003571InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)electrophoretic variant0.000001356Highly InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.4974Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.5627Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.6554Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8184Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.4148Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.4977Moderately InformativeInherited
Zebrafish Anatomy (ZA)head0.6892Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.881Moderately InformativeInherited
Zebrafish Anatomy (ZA)retina0.1983InformativeInherited
Zebrafish Anatomy (ZA)retinal neural layer0.07301Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0.03788Least InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.000002962Moderately InformativeDirect
Xenopus ANatomical entity (XAN)solid compound organ0.0002029InformativeDirect
Xenopus ANatomical entity (XAN)intestine0.0002105InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)collective phyllome structure0.0001274Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0.0002164Least InformativeDirect
Plant ANatomical entity (PAN)sporangium0.001608Least InformativeInherited
Plant ANatomical entity (PAN)whole plant0.002332Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll0.02247Least InformativeInherited
Plant ANatomical entity (PAN)flower0.3199Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.5571Least InformativeInherited
Plant structure DEvelopment stage (PDE)LP.06 six leaves visible stage0.0005289Least InformativeDirect
Plant structure DEvelopment stage (PDE)LP.08 eight leaves visible stage0.0007573Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000000005181InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on the CH-OH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Glycosylases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-carbon lyases1Moderately InformativeInherited
Enzyme Commission (EC)Carbon-oxygen lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Ligases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH group of donors0InformativeDirect
Enzyme Commission (EC)In cyclic amidines0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups0.00000000002338InformativeDirect
Enzyme Commission (EC)Acting on the CH-NH(2) group of donors1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases1InformativeInherited
Enzyme Commission (EC)Transferring alkyl or aryl groups, other than methyl groups1InformativeInherited
Enzyme Commission (EC)Thiolester hydrolases1InformativeInherited
Enzyme Commission (EC)Carbon-nitrogen lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-[acyl-carrier-protein] synthase I0Highly InformativeDirect
Enzyme Commission (EC)Acting on ether bonds0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C=C bonds0Highly InformativeDirect
Enzyme Commission (EC)Shikimate kinase0.00000000000001795Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate dehydratase0.000000000004604Highly InformativeDirect
Enzyme Commission (EC)3-dehydroquinate synthase0.0000000005348Highly InformativeDirect
Enzyme Commission (EC)Fatty-acyl-CoA synthase0.000000005902Highly InformativeDirect
Enzyme Commission (EC)Shikimate dehydrogenase0.000001138Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000005705Highly InformativeDirect
Enzyme Commission (EC)Lovastatin nonaketide synthase0.00002672Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00003278Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0005885Highly InformativeDirect
Enzyme Commission (EC)Acting on hydrogen as donors1Highly InformativeInherited
Enzyme Commission (EC)Acyl groups converted into alkyl groups on transfer1Highly InformativeInherited
Enzyme Commission (EC)Phosphotransferases with a carboxy group as acceptor1Highly InformativeInherited
Enzyme Commission (EC)Ammonia-lyases1Highly InformativeInherited
Enzyme Commission (EC)Other lyases1Highly InformativeInherited
Enzyme Commission (EC)Intramolecular lyases1Highly InformativeInherited
Enzyme Commission (EC)Acid--thiol ligases1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processAmino-acid biosynthesis0Moderately InformativeDirect
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism0Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAromatic hydrocarbons catabolism0InformativeDirect
Biological processGlycolysis0InformativeDirect
Biological processPurine biosynthesis0InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processAntibiotic resistance0.000005467InformativeDirect
Biological processLipid biosynthesis0.007132InformativeInherited
Biological processAntiport0Highly InformativeDirect
Biological processBranched-chain amino acid biosynthesis0Highly InformativeDirect
Biological processChlorophyll biosynthesis0Highly InformativeDirect
Biological processCobalamin biosynthesis0Highly InformativeDirect
Biological processDiaminopimelate biosynthesis0Highly InformativeDirect
Biological processGlucose metabolism0Highly InformativeDirect
Biological processIsoprene biosynthesis0Highly InformativeDirect
Biological processLipopolysaccharide biosynthesis0Highly InformativeDirect
Biological processLysine biosynthesis0Highly InformativeDirect
Biological processMethionine biosynthesis0Highly InformativeDirect
Biological processOne-carbon metabolism0Highly InformativeDirect
Biological processPorphyrin biosynthesis0Highly InformativeDirect
Biological processPotassium transport0Highly InformativeDirect
Biological processPhospholipid metabolism0Highly InformativeDirect
Biological processHistidine biosynthesis0.0000000005134Highly InformativeDirect
Biological processAntibiotic biosynthesis0.000000001137Highly InformativeDirect
Biological processAlkaloid metabolism0.00001005Highly InformativeDirect
Biological processSteroid biosynthesis0.00008115Highly InformativeDirect
Biological processAromatic amino acid biosynthesis1Highly InformativeInherited
Cellular componentMitochondrion0.4414Moderately InformativeInherited
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentPeroxisome0InformativeDirect
Cellular componentMitochondrion outer membrane0.0009115InformativeDirect
Cellular componentLipid droplet0.0000002615Highly InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionNADP0Moderately InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect
Post-translational modificationIsomerase0.00002914Moderately InformativeDirect
Post-translational modificationAcetylation0.00006118Least InformativeDirect
Post-translational modificationADP-ribosylation0.0000001358InformativeDirect
Post-translational modificationS-nitrosylation0.00005476InformativeDirect
Post-translational modificationPhosphopantetheine0Highly InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)lipid metabolism0Least InformativeDirect
UniPathway (UP)amino-acid metabolism4.598e-16Least InformativeDirect
UniPathway (UP)carbohydrate metabolism0.00000000002345Least InformativeDirect
UniPathway (UP)biopolymer metabolism1Least InformativeInherited
UniPathway (UP)cofactor metabolism1Least InformativeInherited
UniPathway (UP)aromatic compound metabolism1Least InformativeInherited
UniPathway (UP)metabolic intermediate biosynthesis0Moderately InformativeDirect
UniPathway (UP)one-carbon metabolism0Moderately InformativeDirect
UniPathway (UP)porphyrin-containing compound metabolism0Moderately InformativeDirect
UniPathway (UP)macrocycle metabolism0Moderately InformativeDirect
UniPathway (UP)organic acid metabolism0Moderately InformativeDirect
UniPathway (UP)membrane lipid metabolism0.00001558Moderately InformativeDirect
UniPathway (UP)antibiotic biosynthesis0.0001451Moderately InformativeDirect
UniPathway (UP)secondary metabolite metabolism0.2276Moderately InformativeInherited
UniPathway (UP)fatty acid metabolism1Moderately InformativeInherited
UniPathway (UP)biopolymer biosynthesis1Moderately InformativeInherited
UniPathway (UP)proteinogenic amino-acid biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate biosynthesis1Moderately InformativeInherited
UniPathway (UP)carbohydrate degradation1Moderately InformativeInherited
UniPathway (UP)lipid biosynthesis1Moderately InformativeInherited
UniPathway (UP)amino-acid degradation1Moderately InformativeInherited
UniPathway (UP)glycan metabolism1Moderately InformativeInherited
UniPathway (UP)nucleotide metabolism1Moderately InformativeInherited
UniPathway (UP)cell wall metabolism1Moderately InformativeInherited
UniPathway (UP)alcohol metabolism1Moderately InformativeInherited
UniPathway (UP)aromatic compound biosynthesis1Moderately InformativeInherited
UniPathway (UP)cellular component biogenesis1Moderately InformativeInherited
UniPathway (UP)L-isoleucine biosynthesis0InformativeDirect
UniPathway (UP)protoporphyrin-IX biosynthesis0InformativeDirect
UniPathway (UP)nucleotide-sugar biosynthesis0InformativeDirect
UniPathway (UP)L-lysine biosynthesis0InformativeDirect
UniPathway (UP)nonprotein amino-acid biosynthesis0InformativeDirect
UniPathway (UP)isoprenoid biosynthesis0InformativeDirect
UniPathway (UP)fatty acid degradation0InformativeDirect
UniPathway (UP)metabolic intermediate degradation0InformativeDirect
UniPathway (UP)fermentation0InformativeDirect
UniPathway (UP)alcohol biosynthesis0InformativeDirect
UniPathway (UP)organic acid degradation0InformativeDirect
UniPathway (UP)tetrahydrofolate metabolism0InformativeDirect
UniPathway (UP)L-arginine biosynthesis6.886e-16InformativeDirect
UniPathway (UP)adenosylcobalamin biosynthesis0.000000000000002048InformativeDirect
UniPathway (UP)Branched-chain amino-acid degradation0.0000000003107InformativeDirect
UniPathway (UP)phenylpropanoid biosynthesis0.000000221InformativeDirect
UniPathway (UP)hormone biosynthesis0.000000258InformativeDirect
UniPathway (UP)toxin biosynthesis0.0000009652InformativeDirect
UniPathway (UP)heterocycle biosynthesis0.000007463InformativeDirect
UniPathway (UP)steroid metabolism0.000007676InformativeDirect
UniPathway (UP)terpene biosynthesis0.0001664InformativeDirect
UniPathway (UP)pigment biosynthesis0.0002853InformativeDirect
UniPathway (UP)polyketide biosynthesis0.0006545InformativeDirect
UniPathway (UP)lipopolysaccharide biosynthesis1InformativeInherited
UniPathway (UP)phospholipid metabolism1InformativeInherited
UniPathway (UP)aromatic amino-acid biosynthesis1InformativeInherited
UniPathway (UP)carbohydrate acid metabolism1InformativeInherited
UniPathway (UP)UDP-alpha-D-glucuronate biosynthesis0Highly InformativeDirect
UniPathway (UP)L-valine biosynthesis0Highly InformativeDirect
UniPathway (UP)chorismate biosynthesis0Highly InformativeDirect
UniPathway (UP)tetrahydrofolate interconversion0Highly InformativeDirect
UniPathway (UP)pyruvate metabolism0Highly InformativeDirect
UniPathway (UP)siroheme biosynthesis0Highly InformativeDirect
UniPathway (UP)L-threonine degradation0Highly InformativeDirect
UniPathway (UP)glycerophospholipid metabolism0Highly InformativeDirect
UniPathway (UP)UDP-4-deoxy-4-formamido-beta-L-arabinose biosynthesis2.314e-16Highly InformativeDirect
UniPathway (UP)L-tyrosine biosynthesis0.000000000000003624Highly InformativeDirect
UniPathway (UP)LPS oligosaccharide biosynthesis0.000000000000007189Highly InformativeDirect
UniPathway (UP)LPS O-antigen biosynthesis0.00000000000005591Highly InformativeDirect
UniPathway (UP)myo-inositol metabolism0.0000000000001829Highly InformativeDirect
UniPathway (UP)alanine degradation0.0000000000002731Highly InformativeDirect
UniPathway (UP)polyol biosynthesis0.00000000001371Highly InformativeDirect
UniPathway (UP)pentose phosphate pathway0.00000000069Highly InformativeDirect
UniPathway (UP)chlorophyll biosynthesis0.00000001691Highly InformativeDirect
UniPathway (UP)galactose metabolism0.000001203Highly InformativeDirect
UniPathway (UP)L-threonine biosynthesis0.000009157Highly InformativeDirect
UniPathway (UP)steroid hormone biosynthesis0.0001319Highly InformativeDirect
UniPathway (UP)poly-(R)-3-hydroxybutanoate biosynthesis0.0003562Highly InformativeDirect
UniPathway (UP)opine metabolism0.00811Highly InformativeInherited
UniPathway (UP)porphyrin-containing compound degradation0.08208Highly InformativeInherited
UniPathway (UP)L-ascorbate biosynthesis0.08941Highly InformativeInherited
UniPathway (UP)aldonic acid degradation0.3717Highly InformativeInherited
UniPathway (UP)sterol biosynthesis1Highly InformativeInherited

Document: UP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 301 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 301 hidden Markov models representing the NAD(P)-binding Rossmann-fold domains superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]