SUPERFAMILY 1.75 HMM library and genome assignments server

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Tyrosine-dependent oxidoreductases family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   NAD(P)-binding Rossmann-fold domains [ 51734]
Superfamily:   NAD(P)-binding Rossmann-fold domains [ 51735] (12)
Family:   Tyrosine-dependent oxidoreductases [ 51751] (70)


Family statistics
Genomes (3,138) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 66,561 523,616 181
Proteins 65,421 514,456 180


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.2912Least InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00000000000009433Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases1Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases0.001489Moderately InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.4637Moderately InformativeInherited
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.000000004136InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.01624InformativeInherited
Enzyme Commission (EC)Alcohol dehydrogenase0Highly InformativeDirect
Enzyme Commission (EC)3-oxoacyl-[acyl-carrier-protein] reductase0Highly InformativeDirect
Enzyme Commission (EC)Transposing C==C bonds0.000000000000002579Highly InformativeDirect
Enzyme Commission (EC)Beta-ketoacyl-acyl-carrier-protein synthase I0.0000000000001536Highly InformativeDirect
Enzyme Commission (EC)Fatty-acid synthase0.000000000005635Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-acetyltransferase0.00000000004633Highly InformativeDirect
Enzyme Commission (EC)Oleoyl-[acyl-carrier-protein] hydrolase0.0000000001359Highly InformativeDirect
Enzyme Commission (EC)3-hydroxypalmitoyl-[acyl-carrier-protein] dehydrat0.0000000004285Highly InformativeDirect
Enzyme Commission (EC)[Acyl-carrier-protein] S-malonyltransferase0.00000006016Highly InformativeDirect
Enzyme Commission (EC)Enoyl-[acyl-carrier-protein] reductase (NADPH, B-s0.000004149Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)syndrome0.3364Moderately InformativeInherited
Disease Ontology (DO)polycystic ovary syndrome0.000332Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.08804Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.4654Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5057Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.02074Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.3009Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.4041Moderately InformativeInherited
Phenotypic Abnormality (PA)Epidermal thickening0.0168InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.01866InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.03199InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.09987InformativeInherited
Phenotypic Abnormality (PA)Adrenal insufficiency0.0003984Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperpituitarism0.0003984Highly InformativeDirect
Phenotypic Abnormality (PA)Palmar hyperkeratosis0.002811Highly InformativeInherited
Phenotypic Abnormality (PA)Plantar hyperkeratosis0.004194Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal eye physiology0.1629InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.6388Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.1599InformativeInherited
Yeast Phenotype (YP)endomembrane system morphology0.05845Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0.0004375Least InformativeDirect
Xenopus ANatomical entity (XAN)alimentary system0.0002622Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)seed development stage0.0003589InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Transferases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on ester bonds1Moderately InformativeInherited
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0.00000113InformativeDirect
Enzyme Commission (EC)Hydro-lyases0.0003643InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.205InformativeInherited
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors1InformativeInherited
Enzyme Commission (EC)Acting on the CH-NH group of donors1InformativeInherited
Enzyme Commission (EC)Carboxy-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular oxidoreductases1InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)Hydroxymethyl-, formyl- and related transferases0Highly InformativeDirect
Enzyme Commission (EC)Acting on carbohydrates and derivatives0Highly InformativeDirect
Enzyme Commission (EC)Transposing C=C bonds0.00000000001991Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0.00000009568Highly InformativeDirect
Enzyme Commission (EC)Thiolester hydrolases0.04325Highly InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Highly InformativeInherited

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 507 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a NAD(P)-binding Rossmann-fold domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]