SUPERFAMILY 1.75 HMM library and genome assignments server

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28-residue LRR family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   RNI-like [ 52047] (3)
Family:   28-residue LRR [ 52048] (2)


Family statistics
Genomes (130) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,754 3,594 8
Proteins 1,665 3,422 5


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)gastrointestinal system disease0.06306Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000797InformativeDirect
Disease Ontology (DO)upper respiratory tract disease0.004181InformativeInherited
Disease Ontology (DO)Crohn's disease0.0001178Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.03186Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.06681Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1153Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.2432Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.3014Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.4517Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.01582Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.09616Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.1709Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.1733Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.1892Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1947Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.2168Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.2174Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.3208Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.3422Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.3892Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual infection0.7111Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Stomatitis0.0001951InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.000474InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0.0006249InformativeDirect
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.001605InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.001905InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating protein level0.01048InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymph nodes0.03162InformativeInherited
Phenotypic Abnormality (PA)Pain0.03574InformativeInherited
Phenotypic Abnormality (PA)Abnormal intestine morphology0.03691InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.05027InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the gastrointestinal tract0.06081InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.1362InformativeInherited
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.0000006981Highly InformativeDirect
Phenotypic Abnormality (PA)Conjunctivitis0.00002289Highly InformativeDirect
Phenotypic Abnormality (PA)Leukocytosis0.00005469Highly InformativeDirect
Phenotypic Abnormality (PA)Uveitis0.00006642Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.0001314Highly InformativeDirect
Phenotypic Abnormality (PA)Myalgia0.0001654Highly InformativeDirect
Phenotypic Abnormality (PA)Arthralgia0.000246Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal C-reactive protein level0.0004941Highly InformativeDirect
Phenotypic Abnormality (PA)Photophobia0.00066Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00272Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.03931Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.222Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.00008857Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0006229Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.002636Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.2038Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3006Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin level0.00009446InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system physiology0.02514InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00001189Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)sterile progeny0Least InformativeDirect

Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0.3429Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.5521Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.8807Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.2698Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.08307InformativeInherited
Xenopus ANatomical entity (XAN)trunk musculature0.0004204Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.009059Moderately InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a RNI-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Internal database links ]