SUPERFAMILY 1.75 HMM library and genome assignments server

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L domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [ 52046] (3)
Superfamily:   L domain-like [ 52058] (8)
Family:   L domain [ 52071] (5)

Family statistics
Genomes (120) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,372 4,134 21
Proteins 803 2,534 11

Enzyme Commission (EC)

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EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)nervous system disease0.001501Least InformativeInherited
Disease Ontology (DO)cell type cancer0Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system cancer0Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.00001819Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0003298Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.005838Moderately InformativeInherited
Disease Ontology (DO)large intestine cancer0InformativeDirect
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.000003598InformativeDirect
Disease Ontology (DO)female reproductive organ cancer0.00005983InformativeDirect
Disease Ontology (DO)lung carcinoma0.0001066InformativeDirect
Disease Ontology (DO)osteosarcoma0.0001548InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.0002052InformativeDirect
Disease Ontology (DO)malignant glioma0.0002989InformativeDirect
Disease Ontology (DO)myeloid leukemia0.002528InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.01394InformativeInherited
Disease Ontology (DO)male reproductive organ cancer0.05145InformativeInherited
Disease Ontology (DO)gastric adenocarcinoma0.000007161Highly InformativeDirect
Disease Ontology (DO)in situ carcinoma0.00006756Highly InformativeDirect
Disease Ontology (DO)sarcoma0.0001617Highly InformativeDirect
Disease Ontology (DO)acute myeloid leukemia0.0009894Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Autosomal dominant inheritance0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0007279Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.001467Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.01704Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.04458Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.08952Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.000005876Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.00004026Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal heart morphology0.00004705Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.00005335Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.0001251Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.0002373Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0005844Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.001893Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.002529Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2004Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2179Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.3256Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.5127Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)postnatal lethality0InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000002798InformativeDirect
Mammalian Phenotype (MP)impaired muscle contractility0.00003475InformativeDirect
Mammalian Phenotype (MP)decreased neuron number0.0001248InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.000135InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.0002069InformativeDirect
Mammalian Phenotype (MP)abnormal heartbeat0.0004735InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord morphology0.0005909InformativeDirect
Mammalian Phenotype (MP)abnormal voluntary movement0.002123InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.002585InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.00359InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa physiology0.00555InformativeInherited
Mammalian Phenotype (MP)abnormal cardiac muscle contractility0.006658InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.009806InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle wall thickness0.009881InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.06145InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.09863InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.1026InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.1314InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.5699InformativeInherited
Mammalian Phenotype (MP)sex reversal0.0000002773Highly InformativeDirect
Mammalian Phenotype (MP)abnormal trigeminal nerve morphology0.000001096Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myelination0.000002589Highly InformativeDirect
Mammalian Phenotype (MP)heart block0.000007461Highly InformativeDirect
Mammalian Phenotype (MP)abnormal atrioventricular cushion morphology0.00001427Highly InformativeDirect
Mammalian Phenotype (MP)decreased birth weight0.00002181Highly InformativeDirect
Mammalian Phenotype (MP)hyperglycemia0.00004146Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.00005089Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.00006919Highly InformativeDirect
Mammalian Phenotype (MP)abnormal locomotor activation0.0004111Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0004861Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cerebellar layer morphology0.0007096Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007522Highly InformativeDirect
Mammalian Phenotype (MP)dilated heart0.01011Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue physiology0.02037Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)viable0Least InformativeDirect

Document: FP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.3526Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4941Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.001629Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.08871Moderately InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.00001765InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00002555InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00008474InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0001137InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0002867InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0008868Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 50 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a L domain-like domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]