SUPERFAMILY 1.75 HMM library and genome assignments server

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Caspase catalytic domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a/b) [ 51349] (147)
Fold:   Caspase-like [ 52128]
Superfamily:   Caspase-like [ 52129] (2)
Family:   Caspase catalytic domain [ 52130] (7)


Family statistics
Genomes (144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,571 4,595 37
Proteins 1,553 4,554 37


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Cysteine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0004285Moderately InformativeDirect
Disease Ontology (DO)cell type cancer0.03269Moderately InformativeInherited
Disease Ontology (DO)melanoma0.0001235Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0005051Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.001349Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.00292Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.002987Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01475Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.03911Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8307Least InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.00000008453Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00007251Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.02067Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.02191Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.03301Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.5894Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.6031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland physiology0.00000009775InformativeDirect
Mammalian Phenotype (MP)abnormal T cell physiology0.0000002159InformativeDirect
Mammalian Phenotype (MP)abnormal neuron physiology0.000005084InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interleukin level0.002304InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.005875InformativeInherited
Mammalian Phenotype (MP)abnormal response to injury0.05107InformativeInherited
Mammalian Phenotype (MP)abnormal innate immunity0.1692InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-18 level0.0000003989Highly InformativeDirect
Mammalian Phenotype (MP)abnormal immune organ physiology0.0000006043Highly InformativeDirect
Mammalian Phenotype (MP)decreased sensitivity to induced cell death0.000002319Highly InformativeDirect
Mammalian Phenotype (MP)abnormal T cell apoptosis0.000004435Highly InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin-1 beta secretion0.00006909Highly InformativeDirect
Mammalian Phenotype (MP)decreased apoptosis0.0000977Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neuron apoptosis0.0002779Highly InformativeDirect
Mammalian Phenotype (MP)decreased susceptibility to infection0.0008934Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.001935Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.01588Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.01588Least InformativeInherited
Worm Phenotype (WP)cell death variant0.0001886Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell death defective0.0005493InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.09938Least InformativeInherited
Fly Anatomy (FA)adult0.1971Least InformativeInherited
Fly Anatomy (FA)somatic cell0.4573Least InformativeInherited
Fly Anatomy (FA)larva0.6368Least InformativeInherited
Fly Anatomy (FA)neuron0.07765Moderately InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Caspase-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]